Electrochemical sensor based on multiwall carbon nanotube-paste electrode for determination of promethazine in pharmaceutical formulations and blood plasma

A multi-walled carbon nanotube modified paste electrode [MWCN-PE] was used for determination of promethazine [PMZ] in drug formulations and blood plasma by cyclic voltammetry [CV] and differential pulse voltammetry [DPV] methods. Results revealed that the MWCN-PE shows an electrocatalytic activity toward the anodic oxidation of PMZ by a marked enhancement in the current response in buffered solution at pH 5.0. At the MWCN/CPE, the anodic peak potential of PMZ was shifted by 28.0 mV to more negative potential in comparison with bare carbon paste electrode. The detection limit for this method was 0.025 micromol L-1. Results indicated that the modified electrode could be employed for the determination of promethazine hydrochloride in pharmaceutical formulations and plasma samples

DFT and molecular docking studies on biological active acridines: the interaction with bovine serum albumin

Acridine derivatives, especially 1,8-dioxo-9-aryl-decahydroacridine represent significant scaffolds in medicinal chemistry. Given the biological properties of such products which are used in drug development, they need to have appropriate carrier. Proteins are generally used as helpful tools in drug delivery. Consequently, molecular docking between these compounds and bovine serum albumin [BSA] has been taken into account. Furthermore, in order to achieve better results, the suggested compounds have been optimized using Gaussian 03 software