ABSTRACT
Objectives: To compare the lipid lowering affects of Atorvastatin in hypertensive dyslipidemic patients receiving Enalapril and Amlodipine
Study Design: Prospective descriptive and comparative study
Place and Duration: Study was conducted by the Department of Pharmacology LUMHS Jamshoro from 2007 to 2009 at Red Crescent Hospital Hyderabad
Methodology: One hundred essential hypertensive dyslipidemic patients were enrolled in the study. Study was approved by the ethical committee. After taking written consent patients were divided into two Groups [A and B] each group comprising of 50 patients. Atorvastatin 20 mg was combined to Group A patients at the bed time along with Enalapril 10 mg in the morning and to group B patients at the same time along with 5 mg of Amlodipine in the morning. Lipid profile was done at the base line and after 03 months [at the end of the study]
Results: At the end of the study when both groups were compared for the lipid lowering effect of Atorvastatin it was found that serum cholesterol reduced to 184.48 in group A [243.26 +/- base line] and 185.08 +/- 15.09 mg/dl in group B [240.44 +/- 31.5mg/dl base line] p value 0.78, LDL Cholesterol in group A decreased to 111.08+6.13 [243.26 +/- 22.70 at the base line] group B the LDL was decreased 104.40 +/- 4.37 which is highly significant HDL cholesterol was increased to 33.502 +/- .05 [29.90+2.65 base line] in group A, while in group B it was increased to 33.40 +/- 2.09 [29.240 at base line] triglycerides were reduced in both groups and the result were not significant. Results were compared and analyzed statistically by the SPSS version 16. Statistically the result was taken as significant. P value
Conclusion: There is significant mean change in the LDL cholesterol in group B [Atorvastatin + Amlodipine]
ABSTRACT
OBJECTIVES: To compare the antihypertensive effect of Enalapril and Amlodipine along with Atorvastatin in hypertensive dyslipidemic patients
STUDY DESIGN: Prospective and descriptive case study
PLACE AND DURATION: Study was conducted by the Department of Pharmacology and Therapeutics, LUMHS, Jamshoro at Red Crescent hospital, Latifabad, Hyderabad, Pakistan from 2007 to 2009
METHODS: One hundred [100] essential hypertensive, dyslipidemic patients were enrolled in the study
Protocol was approved by ethical committee. After taking written consent patients were divided into two groups [A and B[, each comprising 50 patients. Group A received Enalapril 10mg in the morning along with 20mg Atorvastatin at bed time while group B received 5mg of Amlodipine in morning along with 20mg of Atorvastatin at bed time. Blood pressure and lipid profile were done at the start [Baseline] and after 3 months [end of study] by mercury sphygmomanometer. Results were compared and analyzed statistically by using SPSS-V16 at the end
RESULTS: At the end of the study when both groups were compared for antihypertensive effects. It was observed that the both the antihypertensive drugs have significantly lowered the blood pressure separately but when the effects were compared for both groups there was no significant change at the end of study. Enalapril reduced mean systolic blood pressure from 155.7 + 16.38mmHg at baseline to 140.1 + 8.36 mmHg and diastolic blood pressure to 93.6 + 5.81mmHg to 82.6 + 10.65 mmHg [P value 0.001]. Amlodipine reduced the systolic blood pressure from 157 + 16.72 mmHg to 142.1 + 9.37 mmHg and diastolic blood pressure from 95.6 + 7.11mmHg to 81.4 + 11.06 mmHg [P value 0.001]
Mean systolic blood pressure after treatment in group A was 140.1 + 8.36 mmHg and in group B was 142.1 +9.37 and mean diastolic blood pressure in group A and B after treatment was 82.6 + 10.65 mmHg and 81.4 + 11.06 mmHg respectively [P value 0.58]
CONCLUSION: Both drugs individually reduced the systolic and diastolic blood pressure significantly but when compared, there was no significant change noted and both were equally effective