ABSTRACT
Background: Periprocedural myocardial infarction has been a matter of concern for cardiac interventionists and role of high dose statins is being widely studied now a days
Objective: To compare the frequency of peri-procedural non-Q-wave myocardial infarction between patients who received and not received high dose atorvastatin before percutaneous coronary intervention [PCI]
Material and methods:- This randomized controlled study was carried out from 1[st] February, to 31[st] August, 2010 at Ch. Pervaiz Elahi Institute of Cardiology, Multan. A total of 222 patients with unstable angina on chronic statin therapy undergoing PCI were randomized to atorvastatin high dose bolus group I [80 mg,12 hours before intervention, n=l 11] or group II no atorvastatin [n=l 11]
Results: Mean age in group I, was 53 years and in group II, was 55 years. It was noted that majority were female [88%] in group I, whereas Male [92%] in group II. 33% in group I and 37% in group II were diabetics. Similarly hypertension, smoking prevalence was comparable in both groups. Periprocedural MI occurred in 6 [5.4%] patients in group-I and 17 [15.3%] patients in group-II
Conclusion: It is concluded from the study that preloading with high dose [80 mg] atorvastatin bolus before PCI reduces peri-procedural MI in patients on chronic statin therapy undergoing PCI