ABSTRACT
Objective: Chronic kidney disease [CKD] patients have insulin secretion disorders and resistance to insulin effects, that is responsible for the development of cardiovascular events. Vaspin is an adipocytokine that regulates glucose and lipid metabolism. We aimed to determine the serum vaspin levels and its relationship with insulin resistance in CKD patients
Methods: In the study groups, serum vaspin levels, anthropometric parameters and routine blood tests were measured. The serum vaspin levels were examined by the enzyme-linked immunosorbent assay [ELISA] and insulin resistance was determined by the homeostasis model assessment of insulin resistance [HOMA-IR] formula
Results: The serum vaspin, HOMA-IR index and insulin levels were observed significantly high in the CKD group in comparison with the control group. No correlation was found between the serum vaspin level and the anthropometric and metabolic values. The serum vaspin level was positively correlated with the fasting plasma glucose and age but without statistical significance
Conclusion: Insulin resistance and hyperinsulinemia contribute to the development of cardiovascular complications in CKD. We consider that the increase in the serum vaspin level is a consequence of the reduced renal excretion in the CKD and increases in response to insulin resistance
ABSTRACT
Objective: Neutropenia is a serious adverse event that necessitates dosage reduction in patients receiving chemotherapy. In this study, we evaluated the oxidative stress and antioxidant parameters in neutropenic patients after chemotherapy both during the neutropenic period and after successful treatment of neutropenia with filgrastim
Methods: We studied paraoxonase [PON1], arylesterase [ARE], malondialdehyde [MDA], high-density lipoprotein [HDL], lactate dehydrogenase [LDH], and alkaline phosphatase [ALP] in addition to routine biochemical and hematologic parameters. SPSS 12.0 was used for statistical evaluation of data [SPSS, Chicago, IL, USA]
Results: In our study, PON1, HDL, and LDH levels during the period of active neutropenia were statistically significantly higher than these levels were after resolution of neutropenia [P<0.05]; MDA and ALP levels were statistically significantly lower during the period of active neutropenia [P<0.05]
Conclusions: Overall, free oxygen radicals [FOR] were increased and antioxidant parameters were decreased with resolution of neutropenia. This is probably due to FOR produced by the increased number of neutrophils rather than tumor burden