ABSTRACT
Gastric inflammatory myofibroblastic tumor [IMT] is a rare tumor with and unpredictable prognosis usually find in young adults. We present an 18-year-old man with gastric IMT. He complained of epigastric pain, intermittent fever and night sweating associated with weight loss since two years ago. Physical examination showed anemic and cachestic features with mild abdominal tenderness in palpitation as well as an abdominal mass in epigastrium. Abdominal CT scan revealed a huge mass that was arising from the stomach. Upper endoscopy revealed a submucosal lesion in fundus of stomach of approximately 8cm. Endoscopic ultrasound showed a large sub-mucosal non homogenous fundal mass with areas of calcification. The patient underwent laparoscopic partial gastrectomy. Histopathologyand immunohistochemistryevaluation revealed an IMT
ABSTRACT
Colorectal cancer is the second leading cause of cancer death worldwide. Through risk assessment of malignancy in polyps, screening programs can achieve the best results. This study aimed to determine the association between the grade of dysplasia and the location of colorectal polyps. 240 colorectal adenomatous polyps which were referred to department of pathology at Rasoul-e-Akram Hospital between 2005 and 2009 met the inclusion criteria. Demographic data and information about size of polyps, grade of dysplasia and location of polyps were collected and analyzed by Chi-square and t-test. 124 [58.8%] patients were male and 87 [41.2%] were female. The mean age of the patients was 61.6 years. 47 [19.6%] polyps were right-sided and 193 [80.4%] were left sided. 39 [16.2%] polyps had high grade dysplasia. 27 [12.8%] patients had 56 synchronous polyps [23.3%]. 176 [73.3%], 39 [16.2%] and 25 [10.5%] polyps were of tubular, tubulovillous and villous types respectively. The greatest dimension of 110 [45.8%] polyps was <0.5 cm, 97 [40.4%] 0.5-1 cm, 22 [9.2%] between 1 and 2 cm and finally 11 [4.6%] >2 cm. High grade dysplasia was detected in 3 [6.3%] of right-sided and 36 [18.6%] of left-sided polyps. The obtained results revealed that size of polyp and amount of villous component were strongly associated with high grade dysplasia. Left side location of polyps was independently associated with high grade dysplasia. Left-sided colorectal polyps must be treated more seriously, especially the larger ones with villous component. There was no association between age and gender and the grade of dysplasia
ABSTRACT
Myocardial infarction is the major cause of morbidity and mortality in industrialized countries. Platelet count and the mean platelet volume [MPV], a simple and reliable indicator of platelet size which correlates with platelet activation, might associate with troponin in acute chest pain. We analyzed MPV of 851 patients who were admitted to Rasoul-e-Akram Hospital with acute chest pain during the year 2010. Two blood samples were taken from each patient within 4 hours of their arrival for routine hematology, including platelet count and MPV, and cardiac troponin T. Also, electrocardiograms of the patients were recorded. Association of MPV and platelet count with troponin was observed. The patients in troponin positive group, who had also ischemic electrocardiographic changes, had higher MPV values than non- acute coronary syndrome [ACS] patients with normal cardiac troponin T levels [9.9 vs 9.5 fl with p< 0.001]. In troponin negative group, the mean of platelet count was higher than that in the positive group [221683 vs 198814/micro l with p< 0.001]. MPV and platelet count are inexpensive laboratory tests which can be measured in association with other laboratory biomarkers in patients presenting with acute chest pain. This could help to lower hospitalization rates and also avoid misdiagnosis and having complications of patients with ACS
Subject(s)
Humans , Platelet Count , Blood Platelets , Troponin T , Chest Pain , Angina PectorisABSTRACT
Chronic diarrhea is defined as a decrease in fecal consistency lasting for four or more weeks. Prevalence of this complication in the general population is 5%. Mast cells that play an important role in the regulation of gastrointestinal visceral sensitivity and vascular permeability may be involved in functional chronic diarrhea. In this study we tried to evaluate mast cells density in colonic mucosa of patients with chronic diarrhea. 50 patients with chronic diarrhea and 50 persons as control group were investigated. All specimens were immunohistochemically stained for mast cell tryptase [MCT] with monoclonal mouse anti-human MCT as well as toluidine blue. Mean number of mucosal mast cells were counted in 10 high power microscopic fields of patients and control groups. In patients group [age range, 15-78 years; 26 females], the number of mast cells per high power field in the immunohistochemistry staining was 21.3 +/- 4.8 compared to 14.2 +/- 3.4 in the control group [age range, 18-78 years; 24 females] [P < 0.001]. Also number of mast cells in toluidine blue staining was 10.3 +/- 3.6 per high power field in cases and 7.1 +/- 2.4 in the control group [P < 0.001]. Elevated number of colonic mast cells exist in patients with chronic diarrhea. Further research should be considered on application of these findings for new therapeutic opportunities.
ABSTRACT
Latent adenocarcinoma of prostate refers to cases who present no obvious sign or symptom during their life spans and the tumor is incidentally found at postmortem examination. Its frequency can be very important in epidemiologic investigations, prevention and treatment. No previous study has been done in this regard in Iran and the studies performed in other countries show various results. The aim of present study is to determine the frequency of latent prostate carcinoma by studying the corpora of men above 50 years old referred to forensic medicine organization in Tehran in 2008 and 2009. In this study, 149 men aged above 50 who had died of different reasons and undergone autopsy were examined. Their prostates were excised and the slides were studied for the presence of adenocarcioma and prostatic intraepithelial neoplasia [PIN]. In each case, age, weight of prostate, location of lesion, and grading according to Gleason's system were determined and the results were analyzed by SPSS software [version 16]. Out of 149 cases, 34[22.8%] had low grade PIN, 26[17.4%] high grade PIN, and 14[9.4%] invasive adenocarcinoma. Most of the tumors were located in posterior lobe of prostate and they were more frequent in older cases [>65 years of age] and heavier prostates [p value <0.05]. All invasive adenocarciomas were accompanied by PIN. Worldwide studies show lower prevalence of latent carcinoma of prostate in Asian men than white European ones. Considering the absence of such studies in Iran, a larger study to compare and find out the precise rate of this kind of carcinoma, is recommended