ABSTRACT
Objective: This study aimed to evaluate the efficiency of Lactobacillus acidophilus to reduce zearalenone toxicity in vital systems of albino white rats
Methods: Fusarium graminearum isolate was tested to produce zearalenone toxin. L. acidophilus was used to reduce the toxin in rats. This ability was studied by many parameters such as biochemical and physiological parameters in addition to histological study
Results: The results showed that L. acidophilus had the ability to reduce zearalenone toxicity. L. acidophilus had the ability to raise Hb 11 g/dl in blood of animals that was treated with zearalenone only to 13.06 g/dl in animal's blood that was treated with zearalenone + L. acidophilus. As well as the number of red blood cells in animals blood treated with these treatment was 6.62 x 10[12] cell/ L. L. acidophilus reduces the toxicity of zearalenone through its ability to reduce the number of platelets to normal levels
Conclusion: L. acidophilus had a role in repeated biochemical parameters to normal levels. Total protein rose to 6.6 g/dl in animal's blood treated with zearalenone + L. acidophilus compared with these levels in blood of control group. Also GPT and sugar levels in animal blood that was treated with zearalenone + L. acidophilus were at normal level. Histological study proved that L. acidophilus had the ability to protect liver, kidney, and uterus from the toxicity of zearalenone