ABSTRACT
Normocytic anemia is caused by bone marrow hyoproliferation, red cell maturation defects or decreased red cell survival [blood loss/hemolysis]. Osteopetrosis [OP] is a rare, inherited disorder leading to increased bone density on radiographs. It is classified as autosomal recessive [AR] and autosomal dominant [AD] types. AROP [malignant] is a life-threatening condition, which classically manifests in the first few months of life, by short stature, macrocephaly and frontal bossing, blindness, deafness, and facial palsy. The most severe complication of AROP is bone marrow suppression, resulting in pancytopenia and secondary expansion of extramedullary haeatop-oietic sites such as the liver and spleen. The present case report is a case study of a 4-year-old boy presented with severe anemia and other manifestations of malignant AROP with recurrent blood transfusion. After clinical, hematological and radiological evaluation, the diagnosis of osteopetrosis was established.