ABSTRACT
Background: The implications of cardiac risk stratification before orthotopic liver transplantation [OLT] are not well established. We studied the usefulness of myocardial perfusion imaging [MPI] in this scenario
Methods: MPI data of 24 patients [9 females], candidates of OLT, were collected. They underwent MPI as part of their preoperative risk assessment. MPIs were interpreted by 2 nuclear physicians, who had access to clinical data, scan, and semi-quantification results [i.e., quantitative perfusion single-photon emission tomography [SPECT] [QPS] and quantitative gated SPECT [QGS]]. A 3rd nuclear physician, blinded to the clinical history of the subjects, re-reviewed the scans. The visual interpretations of MPI [i.e., normal vs. abnormal], ejection fraction, and transient ischemic dilation index derived from QPS and clinical and follow-up data were collected and analyzed
Results: The follow-up period was 231.0 +/- 86.0 days. The MPIs were normal in 16 [66.7%] patients and abnormal in 8 [i.e., 5 mild [20.8%], 1 [4.2%] moderate, and 2 [8.3%] severe]. Out of 4 patients who died during the follow-up, 1 had mild ischemia and 2 had severe ischemia. A patient who had a normal MPI died due to noncardiac reasons. A patient with abnormal MPI had 3-vessel disease on angiography. Out of the 5 patients who died or had significant coronary angiographic abnormalities, 4 had abnormal MPIs [negative predictive value = 93.8%; sensitivity = 80.0%] The MPIs of 4 patients withoutperioperative mortality or cardiac morbidity were abnormal [specificity = 78.9%]
Conclusion: MPI seems to be remarkable in discriminating high-risk OLT patients preoperatively
ABSTRACT
Introduction: The prevalence of chronic diseases increases with age. Increased production of reactive oxygen species involves in the pathogenesis of cardiovascular diseases such as coronary atherosclerosis, hypertension, diabetic vascular complications, and heart failure. The present study aimed to explore the effects of resistance training on plasma hydrogen peroxide [H2O2] level of ageing women
Methods: Twenty-four postmenopausal women [mean age = 67.37 +/- 6.02, height = 153.02 +/- 8.12, weight = 65.78 +/- 12.03, body mass index = 26.87 +/- 4.16, body fat percent = 18.61 +/- 3.65, and waist-to-hip ratio [WHR] = 0.92 +/- 0.4] were purposefully chosen and randomly divided into control and experimental groups each consisted of 12 subjects. Experimental group did resistance training for eight weeks as follows: three sessions per week with 40% to 65% intensity of a maximum repetition and 5% overload after each 6 sessions. Before and after 8 weeks of training, resting levels of H2O2 was measured and recorded. Data were analyzed by paired- samples t-test
Results: A statistically significant decrease observed in plasma H2O2 level [p = 0.041] and also weight [p = 0.048], body fat percent [p = 0.001], WHR [p = 0.037], resting- heart- rate [p = 0.021], systolic blood pressure [p = 0.006] and diastolic blood pressure [p = 0.002] of participants in experimental group but there were not any statistically different in any of the variables, pre and post-test in control group
Conclusion: Resistance training may be used as an intervention program for cardiovascular risk factors reduction