ABSTRACT
Introduction:Bevacizumab [Avastin], as an effectiveness treatment modality, is currently used in patients with various ocular disease. However the results have been promising, the use of bevacizumab in the treatment of ocular disease is an off-label application. Hence, the aim of this study was to systematically review the effectiveness of intravitreal injection of bevacizumab on various ocular tissues, especially corneal endothelial cells
Methods: The articles related to the effect of application of Avastin in the treatment of ophthalmic diseases and especially its effect on corneal endothelial cells were collected and reviewed. We searched PubMed, Google scholar, and Scopus databases and used Avastin, ocular diseases and corneal endothelial cells as search keywords
Result: Of all 55 articles found in all databases, only 10 were relevant to the purpose of this study, and 45 articles were excluded in several step by step process of article selection according to the inclusion/exclusion criteria. The results revealed that intracameral bevacizumab injection caused no changes in specular microscopy and corneal pachymetry. Moreover, it had no significant toxicity on corneal endothelial cells
Discussion: Effectiveness of bevacizumab as a new modality in the treatment of different ophthalmic diseases have been suggested. Recent data on both human and animal models showed that intravitreal injection of bevacizumab resulted in no significant toxicity on various ocular cells, and it could be considered as a suitable therapeutic approach in clinical use
Conclusion: According to the results of included documents, bevacizumab was not toxic to corneal endothelial cells at various clinically relevant doses
ABSTRACT
Amblyopia is one of the most important reversible eye disorders in childrenand different treatments are suggested. Early diagnosis and effectivetreatment in amblyogenic age are important criteria. These critical periodscorrespond to the period when the child's developing visual system issensitive to abnormal input caused by stimulus deprivation, strabismusor significant refractive errors. Traditional treatments such as glasswearing, contact lens used with patch therapy have limitations. Lasercorneal refractive surgeries introduce an alternative for the treatmentof anisometropic amblyopia. Current indications for refractive surgeryinclude anisometropia, bilateral high myopia and accommodativeesotropia. Several reports confirmed that with recent development inkeratorefractive surgery, it could be a safe method to be used in children.The goal of the permanent surgical treatment is to reduce refractive errors,treat amblyopia and make better the binocular function. Corneal haze iscertainly a major concern in children receiving surface ablation, especiallyin high myopic treatments. However, controversies still exist on whetherit could be done in this population or not. This article reviews the availabledata about refractive surgery for treating anisometropic amblyopia