Evaluation of haptoglobin phenotypes in association with clinical features of patients suffered from preterm labor disease

Preterm birth means the birth before thirty seven week of pregnancy that causes a lot of complications for the baby. Variety factors are suggested to be involved in disease. In this study, we decided to evaluate haptoglobin [Hp] phenotypes association with clinical features of patients suffered from premature delivery to understand better the possible correlation of genetic and clinical features in this disease. This cross-sectional analytic descriptive study has been carried out in two groups of 120 women, 60 with preterm and 60 with term labor. Patients were selected with previously diagnosed by gynecologist with preterm birth in the labor during the study period. After performing diagnostic tests, the frequency of each haptoglobin phenotype in the two groups was analyzed using the Chi-square test [X2] test and SPSS software. The maximum serum haptoglobin phenotype frequency in patients with Hp2-2, was 43 [71.7%] whereas in healthy individuals, 35 [58.3%]. No, statistically significant differences between the two groups were found [p=0.310]. But based on some patients clinical features such as their history of preterm delivery, previous history of recurrent abortions and history of preterm delivery in their family, significant association was found with Hp2-2 compared with healthy control [p<0.003]. This study showed that Hp2-2 phenotypes levels in the case group was higher than in control but the factors influencing the presence or absence of preterm labor is clinically various

Association of haptoglobin phenotypes with clinical features of preterm labor disease

Preterm birth means the birth before thirty seven week of pregnancy that causes a lot of complications for the baby. Variety factors are suggested to be involved in disease. In this study, we decided to evaluate haptoglobin [Hp] phenotypes association with clinical features of patients suffered from premature delivery to understand better the possible correlation of genetic and clinical features in this disease. This cross sectional analytic descriptive study has been carried out in two groups of 120 women, 60 with preterm and 60 with term labor. Patients were selected with previously diagnosed by a gynecologist with preterm birth in hospital during the study period. After performing diagnostic tests, the frequency of each haptoglobin phenotype in the two groups was analyzed using the X2 test and SPSS software. The maximum serum haptoglobin phenotype frequency in patients with Hp2-2, was 43 [71.7%] whereas in healthy individuals, 35 [58.3%]. No statistically significant differences between the two groups was found [P=0.310]. But based on some patients clinical features such as their history of preterm delivery, previous history of recurrent abortions and history of preterm delivery in their family, significant association was found with Hp2-2 compared with healthy control [P<0.003]. This study showed that Hp2-2 phenotypes levels in the case group was higher than in control but the factors influencing the presence or absence of preterm labor is clinically various.

Association of haptoglobin phenotypes with serum levels of IgE and IgA in allergic rhinitis patients

Allergic rhinitis [AR] is an allergic disorder of the nasal tissue that underlies diseases such as sinusitis, otits and asthma. Different predisposing factors including immunological and non-immunological factors contribute to the disease pathogenesis. To investigate association of haptoglobin [Hp] phenotypes [Hp1-1, 2-1 and 2-2] with serum immunoglobulins A and E levels in patients suffering from AR in comparison with healthy individuals. Two hundred and forty patients and 240 healthy individual entered in this case-control study. Serum levels of IgE and IgA were measured and haptoglobulin phenotypes were determined by electrophoresis. The results were evaluated by chi[2] statistical test using SPSS software. Serum electrophoresis showed that the distribution of haptoglobin phenotypes of Hp1-1, Hp2-1 and Hp2-2 among 240 patients were 11.3%, 37.9% and 50.8%, respectively. The distribution of different haptoglobin phenotypes in healthy controls were 88.7%, 36.6% and 54.7%, respectively. However, the difference between patients and controls was not statistically significant [p=0.136]. The mean of IgE level was significantly higher in patients than controls in association with all three phenotypes [p<0.001]. Mean of IgA serum level was also significantly different between case and control groups for Hp1-1 [p<0.048] and Hp2-2 phenotypes [p<0.027]. We conclude that there is an association of all three haptoglobin phenotypes with IgE level. Hp1-1 and Hp2-2 phenotypes showed association with IgA in allergic rhinitis, as well. However, we cannot solely attribute these associations to the pathogenesis of allergic rhinitis