ABSTRACT
Background@#Immune thrombocytopenia (ITP) is a bleeding disorder. Helicobacter Pylori is a Gram-negative bacterium that is presumed to be associated with ITP and therapeutic response of patients. To evaluate the effect of H. Pylori eradication on platelet count of ITP patients, we analyzed the studies conducted on the association between H. Pylori infection and response to therapy in ITP patients in Western Asia focusing on the Middle East region. @*Methods@#A systematic search of databases (PubMed/Medline, ISI Web of Science, Cochrane Central) and Google Scholar search engine results was conducted up until January 2020. The keywords included in the search were Helicobacter Pylori and/or H. Pylori, ITP and/or immune thrombocytopenia. @*Results@#Seven studies comprising a total of 228 H. Pylori -infected patients (193 with successful eradication) were included in this study. The association between H. Pylori eradication and ITP was expressed as odds ratios (OR) and 95% confidence intervals (CI). The findings showed that patients who received eradication treatment for H. Pylori infection had significantly higher OR (OR, 8.83; 95% CI, 2.03‒38.35; P =0.004) than those in the non-eradicated group. @*Conclusion@#Our results indicate a significant therapeutic effect of H. Pylori eradication on the platelet count of patients with chronic ITP. Given the inherent limitations of this study, including the small number of patients, further studies with more patients are recommended.
ABSTRACT
Aim: In This study focused on the detection of dominant clones and genetic relationship of Shigella spp. isolated from children with diarrhea in the main pediatric hospital in Ahvaz by multi-locus sequence typing [MLST] technique
Background: Shigellosis is considered as one of the problematic bacterial infections for public health in the world. Khuzestan province in the Southwestern part of Iran is a known endemic area for infections due to Shigella. There are limited molecular epidemiological data for Shigella spp. in this area
Methods: A total of 50 Shigella spp. were isolated from January-June 2015 based on conventional microbiology and serology tests. The Sequence types [ST] of Shigella isolates which are characterized by Enterobacterial repetitive intergenic consensus [ERIC-PCR] were detected by MLST technique
Results: Among 50 Shigella isolates, a total of 31[62%], 16[32%] and 3 [6%] of Shigella isolates were identified as S. flexneri, S.sonneii, and S.boydii, respectively. Two different sequence types [ST152 and ST245] were identified in Shigella isolates. ST152 was detected in S.sonnei and ST245 in S. flexneri and S. boydii isolates
Conclusion: Based on MLST data, the stable and genetically linked Shigella clones are the cause of Shigella infections in children in Southwestern Iran
ABSTRACT
Infection is one of the most common causes of complication in bum patients. A severe burn injury is not only a life-threatening problem for the burned patients, but it also may have serious financial effects on the patient and society. In a descriptive study, medical files of 6082 consecutive admissions for burn injury treated at Taleghani Burn Hospital over a five-year period were reviewed. The mean age of patients was 22.4 +/- 16.9 years and overall male to female ratio was 1.25. Burns were more common during winter [33.6%] [p<0.001]. Fire accident was the most common cause in all age groups [66.1%], except subjects aged less than 10 years. The percent of TBSA for burned patients ranged between 1% and 100% with a mean of 38.7 +/- 29.8%. There was a correlation between TBSA percentage and age [r=0.18%]. The mean and median hospital stay was 14 and 9 days, respectively, with a range of 1-311 days. There was a significant association between fire accident and hospital stay [p<0.001]. Of 6082 patients, 486 deaths were recorded [8%]. E. colt in urine culture and Pseudomonas aeruginosa in blood and wound culture were the most predominant isolated bacteria. Preventive programs for reducing the risk of burns are needed. Furthermore, high percentage of TBSA and mortality and the presence of multi-drugs resistance bacteria are major concerns in our hospital