ABSTRACT
Liver disease is one of the major health problems in many countries. Mesenchymal Stem cells have opened a new approach to deal with liver fibrosis. Improvement of bone marrow derived mesenchymal stem cellshoming after systemic injection of disintegrin/like domain purified from Egyptian horned Cerastes cerastes crude venomwhichwas shown byprevious study.This work was designed to investigate the possible mechanism of disintegrin/like domainin mesenchymal stern cells homing to fibrotic liver of CCU treated mice. Quantitative gene expression was performed for strornal cell-derived factor-la to study homing of bone marrow derived mesenchymal stem cells, transforming growth factor beta 1 to study bone marrow derived mesenchymal stem cellshoming and regeneration of liver cells and hepatocyte growth factor to study regeneration of liver cells in CCU induced liver injury in white albino mice. It was found that disintegrin/like domaincould increase homing ofbone marrow derived mesenchymal stem cells as showed by the significant increase in liver stromal cell-derived factor -la gene expression, transforming growth factor beta 1 as well as hepatocyte growth factor genes expression compared to the non disintegrin/like domaintreated CCU group
ABSTRACT
To evaluate the utility of measuring different serum lipids in the second trimester of pregnancy for predicting pre-eclampsia in high risk patients. The study comprised 90 pregnant females with high risk of developing pre-eclampsia. Serum measurements of total cholesterol, HDL-C, LDL-C and triglycerides were taken between 18-24 weeks of gestation. Patients were followed up and divided into 2 groups accordingly. Group I [healthy patients], Group II [patients who develop pre-eclampsia]. Serum triglycerides showed a sensitivity of 100%, a specificity of 100%, a PPV of 100% and a NPV of 100% with a total accuracy of 100%. Total serum cholesterol showed a sensitivity of 88.1%, a specificity of 70.83%, a PPV of 72.55% and a NPV of 87.18% with a total accuracy of 78.89%. HLD-C showed a sensitivity of 74.19%, a specificity of 52.54%, a PPV of 45.1% and a NPV of 79.49% with a total accuracy of 60%. Moreover, LDL-C showed a sensitivity of 100%, a specificity of 44.32%, a PPV of 3.92% and a NPV of 100% with a total accuracy of 45.56% and finally TC/HDL ratio showed a sensitivity of 96.43%, a specificity of 61.29%, a PPV of 52.94% and a NPV of 97.44% with a total accuracy of 72.22%. According to the results of the study, the most accurate predictor for the prediction of pre-eclampsia, was the serum triglycerides level, while Total serum cholesterol and TC/HDL ratio came next in accuracy