ABSTRACT
Phytochemical investigation of the methanolic extract of Cyperus rotundus L. [Cyperaceae] rhizomes afforded a new norterpenoid with an unprecedented carbon skeleton, namely cyperalin A [1] and sugetriol triacetate [2]. Their structures were identified by using advanced spectroscopic technique such as UV, IR, 1D [[1]H and [13]C], 2D [[1]H-[1]H COSY, HSQC, HMBC, and NOESY]] NMR, and HRESIMS as well as comparison with literature data. The isolated compounds were evaluated for their anti-inflammatory activity. Compound 1 displayed the highest inhibitory activity of PGE2, COX-2, and LOX-5 with IC[50s] 0.22, 1.03, and 1.37 MuM, respectively compared to indomethacin [IC50s 0.15, 0.69, and 0.81 MuM, respectively]. Moreover, 2 demonstrated significant activity with IC[50s] 0.57 [PGE2], 1.74 [COX-2] and 2.03 [LOX-5] MuM