Anaesthesia and intraocular pressure a comparison of total intravenous anaesthesia using etomidate, with conventional inhalation anaesthesia

Intraocular pressure was measured in two comparable groups of anaesthetised patients under standardized conditions. Group [I] received total intravenous anaesthesia [TIVA] using Etomidate. Group [II] received conventional inhalation anaesthesia with halothane. Both groups were ventillated to normocapnia, B.P, heart rate, central venous pressure and IOP were measured at 5 minute intervals from preinduction to end of procedure. A significant greater reduction in mean IOP [P 0.05] occurs in group [I]. A maximum fall in IOP of 55.9% was obtained, compared to a maximum fall of 40.3% in group [II]. B.P. fell in both group. The fall was greater [20.6%] in group [II], than in group [I] [17.3%]. TIVA using etmidate is suggestive as a useful technique for open eye surgery

Comparative trial of different antimalarial regimens in the treatment of plasmodium falciparum infection with mild cerebral involvement

170 cases of P. Falciparum malaria with mild cerebral involvement was studied. They were given the standard 1500 mg chloroquine orally with 21.7% cure rate. The failures were given the same dose of chloroquine I.M. with 63.63% cure rate. Combination of chloroquine. I.M. or quinine oral with tetracycline 500 mg/6D for 7 days gave the best results of 95% and 75% cure rate respectively. Also hydrocortisone given in large doses for a short period shorten the duration of fever and improve seriously ill patient in a short time with minimal complications

Plasmodium infection and pernicious syndromes

Record of 1420 cases of plasmodium infection-mainly falciparum, but also P. Vivax, P. Malaria and mixed P. Infection [P. Faciparum and vivax] studied in Kuwait and Elthawra hospitals at Sahaa, A.R.Y, during Decmber 1979 to June 1983, have been analysed to establish the prevaence of pernicious syndrome. 1180 cases had P. falciparum, 128 cases P. vivax 66 cases P. Malariae and 46 cases had mixed malarial infection. Pernicious syndrome with single or multiple organ involvement, of which cerebral and hemopoietic complications were the most common [52% and 30% respectively] were seen in 440 cases. While the fewest complications were found in mixed infection [0.98% of cases], the higher one was found in falciparum infection [26.5%]. The early discovery and proper treatment of both simple cases and patients with pernicious symptoms constitute the main chance of recovery from this preventable dise

Assessment of the hypnotic activity of etomidate alone and in combination with either diazepam or thiopentone-sodium in mice

The effect of etomidate alone and in combination with either thiopentone sodium or diazepam was assessed on the sleeping time and muscle strength. The drug was injected intraperitoneally in therapeutic doses in adult albino mice of both sexes and the time for loss and recovery of the righting reflex [R.R.] were recorded. Both drug combinations, according to the results obtained, would give excellent intravenous anaesthesia. However, etomidate-diazeparn would be superior to etomidate-thiopentone, in view of the additive hypno-sedative and myorelaxant properties of diazepam, and the cardio-respiratory depressant potential of thiopentone