ABSTRACT
The objective of this study was to assess the blood levels of cytokines as interleukin-1 B [IL-1 B], interleukin-6 [IL-6] and Epo in anemic patients on regular hemodialysis [HD] and evaluate their relation to the anemic status of those patients. Sera levels of IL-1 B, IL-6 and Epo were measured by ELISA technique in 40 patients on regular HD. The patients were compared with 20 healthy controls. A statistically significant decrease of serum Epo level and a statistically significant elevation for the sera levels of IL-1 B and IL-6 were detected in the patients compared with the controls. A Positive correlation between IL-1 B and IL-6 was detected. Statistically significant negative correlations between IL-1 B and hemoglobin [Hb] level were observed. Also, statistically significant negative correlations between IL-6 and Hb were observed. Hence, these cytokines would be involved in the pathophysiology of end stage renal disease [ESRD] anemic patients