ABSTRACT
Introduction@#Nowadays, there is a growing trend to use natural medicines with low side effects, and research on medicinal raw materials used in traditional medicine has become more widespread. Therefore, it is important to obtain a suitable drug form from <i>Plantago Major</i> L and to conduct chemical and pharmaceutical technology research.@*Material and method@#The research was conducted in the pharmaceutical industry and technology laboratory. A granule formulation with several variants consisting of a concentrated extract and excipients was obtained. The sum of flavonoids of <i>Plantago Major</i> L extracts and Granular Dosage Forms was detected by thin-layer chromatography in a suitable solvent system prepared in the ratio of ethyl acetate, formic acid, glacial acetic acid, and water (100: 11:11:26). The total flavonoid content of the drug forms was determined by spectrophotometry.@*Result@#Technological researches were carried out with lactose and glucose fillers, gelatin 8%, polyvinyl chloride (PVP) 6%, starch 5% binders, talc 1%, magnesium stearate 1% sliding and lubricating agents and the wet granulation method was used to obtain granules in several variants and was determined by using parameters such as particle spill weight and flow quality. In this research, the flow rate of <i>Plantago Major</i> L grains with lactose as a filler and PVP as a binder was -2.8 ± 0.18 g / sec (p <0.001) and the spill weight was -0.54 ± 0.03 g /cm3 (p <0.001). Based on the results of the above research, lactose was added as a filler, PVP as a binder, 6% as a slide and lubricant, 3% as talc and 1% as magnesium stearate, and the granular drug technology was developed by wet granulation. Analysis of the total flavonoids by thin-layer chromatography revealed the same level of yellow-brown spots (Rf = 0.4) on the plate. The total flavonoid content of the granules from <i>Plantago Major</i> L was 3.8 ± 0.2% (p <0.002).@*Conclusion@#In this study, a simple and suitable drug formulation from <i>Plantago Major</i> L was successfully obtained and it was a basic research to make new drug formulations in further needs.
ABSTRACT
Introduction@#According to the annual health report of Mongolia, non-communicable diseases are rising. Digestive system diseases, the second leading cause of morbidity in the population, account for an average of 15.5 percent of all morbidity over the last 10 years. In traditional Mongolian medicine, <i>Plantago Major</i> L has been widely used as a remedy for wound healing, cholangitis, gastric and duodenal ulcers.@*Material and method@#The research was conducted in the pharmaceutical industry and technology laboratory. The leaves of <i>Plantago Major</i> L were chosen as the main raw materials and UV spectrophotometer, shaker, thin-layer chromatographic plates (Silica gel 60 F 254, Germany), and UV light were used in the experiment. The leaves of <i>Plantago Major</i> L were extracted with 40% ethyl alcohol in a soxlet apparatus and evaporated in a vacuum evaporator to obtain a thick extract.@*Result@#Thin-layer chromatographic analysis of granule and ethyl alcohol extracts of <i>Plantago Major</i> L revealed yellow-brown spots (Rf = 0.4) at the same level as the standard substance rutin on the plate, indicating the presence of flavonoids. The highest light absorption was 250 nm when determining the sensitive wavelength of ethyl alcohol extract of <i>Plantago Major</i> L between 200 nm and 520 nm. The total flavonoids contained 3.95 ± 0.17% (p <0.001) in 40% ethyl alcohol extract of <i>Plantago Major </i>L.@*Conclusion@#It was detected that quantitative mass of total flavonoids in liquid extracts from was 3.95±0.17%.
ABSTRACT
Introduction@#According to the annual health report of Mongolia, non-communicable diseases are rising. Digestive system diseases, the second leading cause of morbidity in the population, account for an average of 15.5 percent of all morbidity over the last 10 years. In traditional Mongolian medicine, <i>Plantago Major</i> L has been widely used as a remedy for wound healing, cholangitis, gastric and duodenal ulcers.@*Material and method@#The research was conducted in the pharmaceutical industry and technology laboratory. The leaves of <i>Plantago Major</i> L were chosen as the main raw materials and UV spectrophotometer, shaker, thin-layer chromatographic plates (Silica gel 60 F 254, Germany), and UV light were used in the experiment. The leaves of <i>Plantago Major</i> L were extracted with 40% ethyl alcohol in a soxlet apparatus and evaporated in a vacuum evaporator to obtain a thick extract.@*Result@#Thin-layer chromatographic analysis of granule and ethyl alcohol extracts of <i>Plantago Major</i> L revealed yellow-brown spots (Rf = 0.4) at the same level as the standard substance rutin on the plate, indicating the presence of flavonoids. The highest light absorption was 250 nm when determining the sensitive wavelength of ethyl alcohol extract of <i>Plantago Major</i> L between 200 nm and 520 nm. The total flavonoids contained 3.95 ± 0.17% (p <0.001) in 40% ethyl alcohol extract of <i>Plantago Major</i> L.@*Conclusion@#It was detected that quantitative mass of total flavonoids in liquid extracts from was 3.95±0.17%.