ABSTRACT
Prevalence of thalassemias and/or hemoglobinopathies, particularly hemoglobin E, and cholangiocarcinoma were found more prominently in the lower part of the Northeast of Thailand as compared with the upper part of this region or any other area of the country. The aim of this study was to evaluate if there was coincident distribution or some relationship. Hemoglobin typing by the cellulose acetate method was performed in 111 cases of cholangiocarcinoma, mainly diagnosed by ultrasonography, compared with 146 normal controls. It was found that hemoglobin E trait and beta-thalassemia trait were significantly higher in the former group.
Subject(s)
Adult , Aged , Bile Duct Neoplasms/blood , Bile Ducts, Intrahepatic , Case-Control Studies , Cholangiocarcinoma/blood , Female , Hemoglobin A2/metabolism , Hemoglobin E/metabolism , Hemoglobinopathies/complications , Hemoglobins/metabolism , Humans , Male , Middle Aged , Thailand/epidemiology , beta-Thalassemia/complicationsABSTRACT
It seems that thalassemia and/or hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency (G-6-PD) have some protective effects against malaria infection. To verify this, hemoglobin typing and methehoglobin reduction test were performed on 115 malaria patients and compared with controls. It was found that the number of thalassemia/hemoglobinopathies in the malaria group and in the control group were not significantly different and also occurrence of G-6-PD deficiency in the malaria group was not different from that of the controls. Clinical manifestations of malaria in any group are quite similar. It is concluded that there is no protective effect against malaria in thalassemia/hemoglobinopathies or G-6-PD deficiency.
Subject(s)
Adolescent , Adult , Aged , Cross-Sectional Studies , Developing Countries , Erythrocytes/enzymology , Female , Glucosephosphate Dehydrogenase/blood , Glucosephosphate Dehydrogenase Deficiency/enzymology , Hemoglobinopathies/enzymology , Humans , Incidence , Malaria/enzymology , Male , Middle Aged , Risk Factors , Thailand/epidemiology , Thalassemia/enzymologyABSTRACT
The efficacy of two formulations, wettable powder and emulsifiable concentrate, of cyfluthrin sprayed on plywood [10 mg (ai)/m2] was assessed against six species of mosquitos. The bioassay followed the WHO standard method, with some modification for the bioassay of insecticidal deposits on wall surfaces. The results indicated that these two formulations of cyfluthrin were effective against Anopheles dirus and Mansonia uniformis, moderately toxic to Aedes aegypti and Ae. albopictus in decreasing mortality through out the study period. It was least effective against Culex quinquefasciatus and An. maculatus, respectively. There was no statistically significant difference between these two formulations.