ABSTRACT
Background@#Reduced harvest volumes in pediatric donors appear to have the potential to reduce donor-associated risks while maintaining engraftment in recipients; however, the allowable harvest volume reduction remains undefined. @*Methods@#We retrospectively analyzed the data pairs of 553 bone marrow (BM) harvests from pediatric (age at harvest ＜18 yr) sibling donors and clinical outcomes of 553 pediatric (age at infusion ＜14 yr) transplant-naïve recipients to assess the optimal BM harvest volume needed from pediatric donors to obtain the desired CD34+ cell count (≥3.0×10 6 cells per kg of recipient weight), and to study its impact on the clinical outcomes of transplantation in pediatric recipients. @*Results@#The minimum desired CD34+ cell count of ≥3.0×10 6 per kg of recipient weight was achieved for 506 (95.3%) of donor-recipient pairs. The median CD34+ cell yield was 6.4×10 6 per kg of recipient weight (range, 1.2‒33.8×10 6 ) in donors younger than 5 years old at harvest, 4.7×10 6 (range, 0.3‒28.5×10 6 ) in donors aged 5‒10 years and 2.1×10 6 range, 0.3‒11.3×10 6 ) in donors older than 10 years (P ＜0.001). @*Conclusion@#The infused CD34+ cell dose (×10 6 cells/kg of recipient weight) had no impact on GRFS; however, a CD34+ cell dose of ＞7×10 6 cells/kg of recipient weight did not improve hematopoietic recovery
ABSTRACT
To find out the age and sex distribution, type of foreign bodies, their mode of presentation, site of impaction, risk factors involved. Experimental study. This study was carried out in the ENT Department, Nishtar Hospital, Multan from January 2012 to December 2012. A total of 100 cases presented with history of FB ingestion were included. Male patients with FB ingestion were 67% and female were 33%. Male to female ratio was 2:1. Patient's age ranges from 6 months to 70 years. Most of the patients were below the age of 10 years. Majority of the patients belonged to lower socio-economic group and also from the rural areas. In total review of nature of foreign body, regardless of age, coin was the commonest F.B [76%]. In the present study rigid oesophagoscopy was done for removal of all F.B. When diagnosis is delayed, or presentation is late, complication rate increases. Do not let foreign body to pass down spontaneously after 24 hour, after that it should be urgently removed under GA without further delay
ABSTRACT
To determine the types, management and complications of tracheohronchial foreign bodies. cross sectional study. This study was conducted at ENT Department of Nishiar Hospital Multan from January 2010 to December 2011. 150 patients underwent rigid bronchoscopy under general anesthesia after routine investigations and x-rays chest where feasible. A total ISO patients underwent bronchoscopy for diagnostic as well as therapeutic purposes. Most common foreign bodies were peanuts [40.66%], beetle nuts [18.669/o] and whistles [18.66?/o]. In 137 [91.33%] patients, foreign bodies were removed on bronchoscopy at first attempt. 10 [6.67%] cases were diagnostic and only 2 [1.33%] cases were subjected to open surgical removal. One [0.67%] of the patients died in ICU after removal of foreign body. Early diagnosis and timely management of foreign bodies with bronchoscopy saves patients life and avoids complications. Younger children should not be offered peanuts, whistles or toys that can be inhaled