ABSTRACT
El herpes simple tipo I es una patología infecciosa e inflamatoria de tipo vírico que se caracteriza por la aparición de lesiones ulcerativas extra orales, de duración aproximada de 14 días y que provocan gran picazón e incomodidad a las personas que lo padecen. El objetivo de este trabajo fue evaluar el uso la Melissa officinalis (toronjil) como terapia alternativa sobre el tiempo de remisión y el número de las lesiones extraorales en pacientes con herpes simple del comparado con el Aciclovir tópico al 5% como terapia convencional. Se realizó un ensayo clínico, aleatorizado y enmascarado simple, controlado. Se evaluó a 34 pacientes con lesiones herpéticas extra orales activas en la etapa primaria vesiculosa, sin patologías asociadas a alteraciones del sistema inmunológico como diabetes mellitus, alergias e hipertensión arterial. Se les administró el tratamiento tópico y se les evalúo diariamente las lesiones herpéticas. La Melissa officinalis posee un efecto antiviral sobre lesiones herpéticas tipo 1 al igual que el Aciclovir tópico al 5%, pero la Melissa officinalis es más efectivo en la disminución de días con lesiones herpéticas (valor p=0,05). La Melissa officinalis tiene un efecto antiviral positivo sobre lesiones herpéticas tipo 1, disminuyendo el número total de días con las lesiones herpéticas en comparación con el Aciclovir tópico al 5%.
Herpes simplex type I is an infectious viral and inflammatory disease type which is characterized by the appearance of extra- oral ulcerative lesions of approximately 14 days that cause severe itching and discomfort for those who have the lesions. The objective of this study was to evaluate the use of Melissa officinalis (lemon balm) as an alternative therapy on remission time and the number of extra oral lesions in patients with herpes simplex compared with topical 5% acyclovir and conventional therapy. A clinical, randomized and single-blind, controlled trial study was carried out. Thirty-four patients were evaluated with active extra- oral herpetic vesicular lesions in primary stage, without pathologies associated with immune system disorders such as diabetes mellitus, allergies and hypertension. They were given topical treatment and herpetic lesions were evaluated daily. Melissa officinalis has an antiviral effect on type 1 herpes lesions as 5% topical acyclovir, Melissa officinalis but is more effective in the reduction of days with herpetic lesions (p value <0.05). In conclusion, Melissa officinalis has a positive antiviral effect on type 1 herpes lesions, reducing the total number of days with herpetic lesions compared with topical 5% acyclovir.
Subject(s)
Aged , Humans , Male , Anticoagulants/adverse effects , Cerebral Hemorrhage/diagnosis , Pituitary Apoplexy/diagnosis , Warfarin/adverse effects , Anticoagulants/therapeutic use , Atrial Fibrillation/drug therapy , Cerebral Hemorrhage/chemically induced , Diagnosis, Differential , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Warfarin/therapeutic useABSTRACT
Antecedentes: Abordagem endoscópica endonasal expandida (AEEE) em cirurgia de base de crânio (CBC) é uma alteração significativa das práticas atuais. Métodos: Analisamos nossa experiência na Universidade de Pittsburgh com AEEE para 800 pacientes de 1998 a julho de 2007. Resultados: Acessos modulares para múltiplas patologias de base do crânio foram concebidos totalmente baseados na anatomia intrínseca da região. Fases de treinamento foram estabelecidas em função do nível de dificuldade técnica e o potencial de risco de lesões vasculares e neurais. Cinco níveis foram definidos de forma incremental. Conclusões: Padronização prática, com formação modular e incremental, é projetada com o intuito de proporcionar aprendizado de modo organizado e seguro das AEEE para a base do crânio. Sugerimos adesão a um programa sistemático de aquisição de habilidades endoscópicas, trabalhar em equipe integrada de cirurgiões e ter amplo domínio tanto da CBC convencional quanto de cirurgia endoscópica. Por isso, a escolha do método cirúrgico deve ser em função específica da anatomia e patologia e não decorrente de viés ou falha de experiência do cirurgião com abordagens alternativas.
Background: Endoscopic endonasal approach (EEA) for skull base surgery (SBS) is a significant modification of the current practice.Methods: We reviewed our experience at the University of Pittsburgh with EEAs for 800 patients from 1998 to July 2007. Results: Modular approaches to multiple pathologies of the skull base were designed totally based on intrinsic anatomy. Stages of training were established based on the level of technical difficulty and potential risk of vascular and neural injury. ive levels were defined in an incremental manner. Conclusions: Practice standardization with modular, incremental training is projected to facilitate the gaining of knowledge and skills to safely master EEAs for SBS in an organized manner. We suggest adherence to the systematic acquisition of ndoscopic skills, to work as an integrated team of surgeons and to have a thorough perspective of conventional SBS and endoscopic surgery. Therefore, the choice of approach must be a specific function of the anatomy and pathology rather than the surgeons bias or lack of experience with alternative approaches.
Subject(s)
General Surgery , Learning , SkullABSTRACT
1. The level of lactic acid was found to be 25 mg percent in 95 percent of 186 normal Indians. There was no difference due to sex and age. 2. Level of lactic acid was estimated in blood of normal persons and diabetics Type II patients to observe the effects of food and glucose. There was no change except the level of lactic acid was in higher but in normal range. 3. Hyperglycemia of over 300 mg raised the blood lactic acid in 25 percent of patients. 4. Lactic acid was not affected by hypercholesteremia but was raised in 60 percent of cases with raised blood urea. 5. Lactic acid was found to remain within normal limits in 48 type II diabetics treated with phenformin dose varying from 50 mg to 225 mg per day. The duration of treatment varied from one year to seven years.
Subject(s)
Diabetes Mellitus, Type 2/blood , Diet , Female , Humans , Hypercholesterolemia/blood , Hyperglycemia/blood , India , Lactic Acid/analysis , Male , Phenformin/administration & dosage , Reference Values , Urea/bloodABSTRACT
A case of Von Hippel-Lindau's disease lacking the classical Lindau's tumour is reported. The uncommon features of this case are highlighted and the relevant literature is briefly outlined.