New onset diabetes mellitus after renal transplantation: impact of immunosuppresssive and antihypertensive therapy

The purpose of the present study was to assess the influence of immunosuppresssive and antihypertensive therapy in the diabetic state after renal transplantation especially impaired fasting glucose [IGF], and impaired glucose tolerance [IGT]. A total of 67 consecutive renal transplant recipients without previously known diabetes underwent a 75gm oral glucose tolerance test [OGTT] 3 months after renal transplantation. BMI, daily prednisolone dose, creatinine clearance, hypertension, number of antihypertensive agents and the use of diuretics or 3 blockers were POSITIVELY associated with, impaired glucose tolerance [IGT], namely impaired fasting glucose [IGF], and abnormal glucose tolerance [ACT] [p<0.05]. After multiple regression analysis, BMI [p<0.001], daily prednisolone dose [p<0.001], cytomegalovirus infection [p<0.03], and triglycerides [p<0.034], were shown to be independent predictors of posttransplant ACT. Increasing daily prednisolone dose is an independent predictor of impaired fasting glucose after renal transplantation. Hypertension and the use of diuretics and beta blockers may also deteriorate glucose tolerance [CT] in this group of patients

Effects of aerobic exercise on control of hyperglycemia in type II diabetes mellitus.

This study was carried out to evaluate the effects of exercise on the diabetic control of 22 female patients with type II diabetes mellitus. A regular aerobic exercise was done every other day for 30 minutes over a period of four weeks. At the end of the study, blood sugar, blood lipids and body mass index were compared with the same parameters at the start of the study. The results showed that there was a significant decrease in fasting and postprandial blood sugar level. The fasting blood glucose was decreased from 179.6 +/- 76.3 mg/dl to reach 149.5 +/- 69.7 mg/dl, this was statistically significant. Postprandial blood glucose decreased from 239.5 +/- 88.8 mg/dl to reach 204.1 +/- 97.1 mg/dl, this was statistically significant. Also, there was a significant decrease in serum triglycerides after exercise. The fasting serum triglyceride before exercise was 122.5 +/- 42.2 mg/dl and after the exercise was 106.8 +/- 341 mg/dl, this was statistically significant. The decrease in serum cholesterol, LDL and body mass index had no statistical significance and also the changes in HDL were of no statistical significance