The Effect of Soluble Fiber Supplementation on Metabolic Syndrome Profile among Newly Diagnosed Type 2 Diabetes Patients

Diets with high fiber content improve most metabolic syndrome (MetS) profile in non-diabetic individuals, but there is scarce information about the role of fiber intake in patients with the MetS and diabetes. The objective of this study is to determine whether soluble fiber supplementation improve MetS profile for 8 weeks of intervention in newly diagnosed type 2 diabetes (T2D) adult patients. After one week of dietary stabilization phase, 36 newly diagnosed T2D patients were stratified to different strata according to sex, age, fasting blood sugar (FBS), and waist circumference (WC). Then they were randomly allocated into 2 groups. The psyllium group (n = 18) received 10.5 g of psyllium daily for 8 weeks. The control group (n = 18) maintained their regular diet for 8 weeks. Soluble fiber supplementation showed significant reduction in the majority of MetS profile; FBS (43.55 mg/dL, p < 0.001), triglyceride (37.89 mg/dL, p < 0.001), total cholesterol (20.32 mg/dL, p < 0.001), systolic blood pressure (7.50 mmHg, p < 0.001), diastolic blood pressure (2.78 mmHg, p = 0.013), and WC (2.54 cm, p < 0.001) in the intervention group compared with the control group after 8 weeks of intervention. The high-density lipoprotein cholesterol was reduced in both groups, but this reduction was insignificant. The improvement in the MetS profile was enhanced by combining psyllium to the normal diet. Consumption of foods containing moderate amounts of these fibers may improve MetS profile in newly diagnosed T2D patients. This study was registered in Current Controlled Trials (PHRC/HC/28/15).

effect of apple cider vinegar and grape vinegar on lipid profile in albino white rats

This study was designed to determine and compare the effect of apple and grape vinegars on lipid profile in male Albino White rats. Fifty male albino white rats [Wt.200-300 gram] divided into five groups with 10 rats in each group. The control group [G1] was fed standard animal food. Group 2 [G2] and group 3 [G3] were fed apple cider vinegar in their food for 4 weeks [3%, 6%, respectively], while group 4 [G4] and group 5 [G5] were fed grape vinegar in their food for 4 weeks [3%, 6%, respectively]. Blood samples were collected at the start and at the end of the experiment to assess total cholesterol [TC], triglyceride [TG], high density lipoprotein cholesterol [HDL-c] and low density lipoprotein cholesterol [LDL-c]. Results showed significant reduction in TC, TG, and LDL-c, associated with significant elevation in HDL-c after 4 weeks of vinegar feeding. The significant changes seen upon vinegar feeding on lipid profile were directly correlated with the concentration used. In conclusion, vinegars would have beneficial effect in cardiovascular disease reduction

Comparative study on renoprotective effect of aliskiren-pentoxifylline combination, valsartan and enalapril among patients with hypertension, type 2 diabetes mellitus and diabetic nephropathy

This study was conducted to evaluate the renoprotective effect of aliskiren-pentoxifylline combination and compare it with enalapril and valsartan in patients with hypertension, type 2 diabetes mellitus and diabetic nephropathy [DN]. Sixty patients with hypertension, type 2 diabetes mellitus and microalbuminurea [20-200microg/min or 30-300mg/24h] were selected from UNRWA and private clinics in Ga/a Strip and divided into three groups. The first group [n=20] was treated with enalapril [10-20mg/day], the second group [n=20] was treated with valsartan [I60mg/day], whereas the third group [n=20] was treated with aliskiren-pentoxifylline combination [150,400mg/day]. All patients were follovved-up for nine months by measuring serum creatinine level and urinary albumin excretion [UAE] rate before and at 3, 6 and 9 months of treatment. Paired T-test and independent T-test were used to analyze our results and the significance was tested at p< 0.05. The results showed a significant reduction in both UAE rate and serum creatinine level among patients who used aliskiren-pentoxifylline combination after 6 and 9 months of treatment, where the reduction was highly significant after 9 months of treatment [p=0.001 for UAE, p=0.000 for serum creatinine level]. In the valsartan treated group, the reduction in UAE rate was significant [p=0.045] after 9 months of treatment, while no significant reduction was noticed in serum creatinine level [p=0.807]. Moreover, no significant reduction was seen in UAE rate [p=0.125] and serum creatinine level [p=0.445] among patients who were given enalapril. In conclusion, aliskiren-pentoxifylline combination showed renoprotective effect more distinct than enalapril and valsartan among patients with DN

Prevalence of malnutrition and intestinal parasites among preschool children in the Gaza strip

Helminthiasis is one of the public health problems worldwide. This is especially true in Gaza Strip. This study demonstrated the parasites prevalent among mal-nutritional preschool-children according to the anthropometric cutoff points [WHO, 2007] and their family socio-demographic variability

[Adequacy of glycemic control and serum lipid profile in hemodialysis of Palestinian patients with diabetes mellitus]

Inadequate glycemic control and lipid abnormalities which are prevalent among diabetic patients on hemodialysis may act synergistically to place these patients at an augmented risk for morbidity and mortality of diabetic complications. The purpose of this case-controlled study was to assess the glycemic control and prevalence of dyslipidemia among diabetics who were on hemodialysis, by following them up for ten months and carrying out the following measurements, glycated hemoglobin [A[1c], LDL, HDL, total cholesterol, and triglycerides, over the time of study, from Nov 2007 to Aug 2008. Fifteen patients died during the study period, ten of them had history of hypertension before reaching the chronic renal failure. The results showed a significant elevation in A[1C]% among the patients in comparison to healthy controls. More than 40% of patients were with inadequate glycemic control [A[1c] >6.5%]. More than half [55.6%] of patients who underwent insulin therapy were with inadequate glycemic control. Dyslipidemia was characteristic in patients where the levels of HDL-C were found to be significantly lower in all patients compared to controls 32.5 +/- 8.8 vs. 42.7 +/- 9.1 mg/dl; respectively. The mean LDL/HDL ratio in patients was higher than in controls, 3.6 +/- 1.3 vs. 2.7 +/- 0.8; respectively. Inadequate glycemic control in diabetics on hemodialysis was prevalent, insulin resistance is suggested, dyslipidemia is predominate, and further follow up of these patients is recommended

Adequacy of glycemic control and serum lipid profile in hemodialysis of Palestinian patients with diabetes mellitus

Inadequate glycemic control and lipid abnormalities which are prevalent among diabetic patients on hemodialysis may act synergistically to place these patients at an augmented risk for morbidity and mortality of diabetic complications. The purpose of this case-controlled study was to assess the glycemic control and prevalence of dyslipidemia among diabetics who were on hemodialysis, by following them up for ten months and carrying out the following measurements, glycated hemoglobin A[1c], LDL, HDL, total cholesterol, and triglycerides, over the time of study, from Nov 2007 to Aug 2008. Fifteen patients died during the study period, ten of them had history of hypertension before reaching the chronic renal failure. The results showed a significant elevation in A[IC]% among the patients in comparison to healthy controls. More than 40% of patients were with inadequate glycemic control [A[IC] >6.5%]. More than half [55.6%] of patients who underwent insulin therapy were with inadequate glycemic control. Dyslipidemia was characteristic in patients, where the levels of HDL-C were found to be significantly lower in all patients compared to controls 32.5 +/- 8.8 vs. 42.7 +/- 9.1 mg/dl; respectively. The mean HDL/LDLratio in patients was higher than in controls, 3.6 +/- 1.3 vs. 2.7 +/- 0.8; respectively. Inadequate glycemic control in diabetics on hemodialysis was prevalent, insulin resistance is suggested, dyslipidemia is predominate, and further follow up of these patients is recommended