ABSTRACT
Present study was aimed to explore a traditionally used indigenous medicinal plant Boerhavia repens [Nyctaginaceae family] of the Cholistan desert, Pakistan. Crude aqueous and methanolic extracts of the whole plant were investigated in vitro for preliminary phytochemical screening, antioxidant and antiglycation activities. Antioxidant activities were determined by total phenolic contents, 1,1-diphenyl-2-picrylhydrazyl [DPPH] free radical scavenging and inhibition of lipid peroxidation. For antiglycation activities browning production was noted and thiobarbituric acid [TEA] technique was used to determine glycation level. Boerhavia repens expressed considerable amounts of phytochemicals. Extract yield was found to be 4.59%-7.85% g/100g of dry matter with total phenolics ranging from 47.9- 190.77mg/GAE per g for aqueous and methanol extract respectively. Strong inhibitory effect was exhibited by methanolic extract in linoleic acid per oxidation system [86.11%, EC[50]=0.99mg/mL] and DPPH assay [88.65%, EC[50] =212.33 Lig/ml]. In term of browning maximum inhibition [81.50%] was exhibited by methanolic extract at 37°C at third week of incubation. Both extracts expressed significant [P>0.05] and comparable inhibition of glycation level. In conclusion, Boerhavia repens showed promising antioxidant and antiglycation activities validating its therapeutic potential
ABSTRACT
A survey of a total of 208 fracture complete dentures was undertaken. The results showed that, by far, the most common area of fracture was the midline in both the upper and lower dentures. Most of the fractures occurred during function. The majority of repairs made with cold-cure acrylic. It is perhaps relevant to mention that it could be thoroughly examined prior to hastily repair them without knowledge of the cause of fracture. If the reason is an ill-fitting denture because of excessive resorption and increased stresses, the dentures should be adjusted as well as repaired. Also, patient's education could help in reducing the incidence of accidental fracture. Dentures should be always cleaned above a bowl filled with water, which acts as a cushion to protect them against breakage if accidentally dropped