ABSTRACT
To determine the efficacy of clarithromycin in the treatment of Pityriasis Rosea [PR]. Double blind randomized controlled trial. Dermatology OPD, Military Hospital, Rawalpindi, from July 2008 to July 2009. Patients aged above 10 years, diagnosed with PR, were randomly assigned to two groups of 30 each to receive either clarithromycin or similar-looking placebo for one week. Neither the patient nor the treating physician knew to which group the patient belonged. Patients were assessed at 1, 2, 4 and 6 weeks after presentation and compared for complete, partial or no response. Among the 60 patients, no significant difference was found between the two groups at 2 weeks after presentation [p = 0.598]. In the placebo group, complete response was seen in 20 [66.7%], partial response in 3 [10.0%] while no response was seen in 7 [23.3%]. In clarithromycin group, there was complete response in 23 [76.7%], partial response in 3 [10.0%] and no response in 4 [13.3%] patients. Clarithromycin is not effective in treatment of pityriasis rosea
ABSTRACT
Pyogenic granulomas [Granuloma telengiectaticum] or tabular capillary haemangioma are classically described as solitary lesions, occurring in young individuals, usually at the site of previous trauma, with a tendency to recur after treatment. We describe an unusual case of multiple disseminated pyogenic granulomas in an elderly male caucasoid of Pakistani origin in whom more than 400 lesions occurred de novo without any antecedent history of trauma or skin disease, responded well to treatment and showed no tendency for recurrence. Multiple eruptive pyogenic granulomas are probably a rare subset of the disease, which can occur at any age, arise de novo or in association with a skin or systemic disease and do not exhibit a tendency to recur after treatment
ABSTRACT
Leishmaniasis is a major world health problem, which is increasing in incidence. New cases of cutaneous leishmaniasis are being reported in Pakistan from previously non-endemic areas. This protozoal disease is transmitted by sandflies and may produce a variety of clinical pictures, including some rare and unusual presentations. Treatment is often delayed due to poorly managed cases, non-availability of laboratory facilities or appropriate drugs. Atypical presentations can sometimes perplex even the most experienced. Early diagnosis and treatment with correct dosage of antimony are essential for and effective outcome. This review focuses on the different aspects of cutaneous leishmaniasis with especial emphasis in context of Pakistan
ABSTRACT
Mucocutaneous leishmaniasis is considered to be a disease of the New World. It has rarely been reported from our part of the world. A 2-year-old child reported from an endemic area of cutaneous leishmaniasis with clinically suggestive lesions of CL over cutaneous as well as mucosal surfaces of the lip and nose. Diagnosis was confirmed on slit skin smear preparation and he was treated with intramuscular injection of meglumine antimonite [glucantime]. A brief review of the condition is also presented along with the case report