Potential anti-inflammatory effect of Cissus quadrangularis L. and Lepedium sativum L. along with their combination extracts

The anti inflammatory activity of methnolic root extract of Cissus quadrangularis L. [CQ] and seed extract of Lepedium sativum L. [LS] were studied in rats also in conjunction with using a mixture [CL] of CQ and LS. The estimation of anti-inflammatory activity was conducted by measuring volumetrically with the help of plethysmometer, the mean increase in hind paw volume of rat. Standard drug like diclofenac sodium within the dose of a 100 mg/kg is used. The doses of 50, 100 and 200 mg/kg of both plant extracts individually as well as combination were given. 0.9% NaCI [saline] solution given to control group. All the doses administered orally. Results showed that at dose of 50mg/kg showed potent activity by LS[4.06+/-0.03] and CQ[4.16+/-0.03], as CL [3.96+/-0.03] showed moderate activity while dose 100 and 200 mg / kg showed moderate activity by LS from respective standard i.e. Diclofenac Sodium

Kinetic studies on zingiber officinale

The present investigation deals with the isolation, purification and characterization of gingerol, the major pungent constituent of ginger [Zingiber officinale] and its kinetic of extraction using a number of organic solvents. The characterization was carried out through GC and GC-MS. Gingerol has been assayed in the plant material during extraction with various solvents by a HPLC method. In order to develop a relationship between solvent characteristics such as viscosity and dielectric constant and the rates of extraction, the kinetics of extraction of gingerol has been studied by using twelve different solvents in order to evaluate the solvent efficacy in the extraction processes. It has been observed that both solvent viscosity [1/v] and dielectric constant show a linear relationship with the rates of extraction [k]. An increase in solvent viscosity leads to a decrease in the rates of extraction, similarly an increase in dielectric constant also leads to a decrease in the rates of extraction. This appears to be largely due to an unionizable character of gingerol which does not interact with polar solvents. Thus solvent viscosity and dielectric constant both play an important role in the choice of solvents for the extraction of gingerol. Sovlents with relatively low viscosity and dielectric constant are more suitable for the extraction of gingerol from plant material