ABSTRACT
This study investigates the effects of hydro-alcoholic extract of Prangos ferulacea [L.] Lindle [P.f] on rats' pancreas structure changes and diabetic treatment after streptozotocin injection. In this research forty male Wistar rats with body weights of 100 +/- 20 gram, were randomly divided into 5 groups with 8 rats per each group. Diabetes was induced in rats by streptozotocin at a dose of 75 mg/kg body weight [B.W] injected intraperitoneally. Root and leaves with stems hydroalcoholic extract of P.f at a dose of 100 mg/kg B.W have been injected orally in diabetic rats, daily for a month. Significant decrease in blood glucose, WBC and HbA1c and increase in body weight were observed in treated diabetic rats. Histopathologic results of diabetic rats revealed reduction in number of pancreatic islets as well as their number of beta-cells and insulitis with lymphocytes infiltration. Regeneration of pancreatic islets and beta-cells, along with a reduction in the number of infiltrated lymphocytes were present in plant extract -treated diabetic rats. The roots´ hydro-alcoholic extract of P.f seems to be capable to regenerate the islets of Langerhans in the treated rats in comparison with the untreated diabetic rats. This property can be due to some components of the plant that can increase insulin secretion
ABSTRACT
Diabetes mellitus is associated with biochemical, physiological and pathological alterations in the liver. The aim of this study was to investigate the effects of hydroalcoholic extract of Prangos ferulacea [L.] Lindle [P.f] on changes in rats´ liver structure and serum activities of alanin and aspartate aminotransferases after alloxan injection. In this study, forty female Wistar rats with body weight of 200 +/- 20 g were randomly divided into 5 groups with 8 rats per group. Diabetes was induced in rats by alloxan monohydrate at dose of 120 mg/kg body weight [BW] injected intraperitoneally. Root and leaves with stems hydroalcoholic extract of P.f at dose of 100 mg/kg BW were given orally in diabetic rats daily for a month. In diabetic rats [D] the serum allanin aminotransferases [ALT] and aspartate aminotransferases [AST] were significantly increased [p<0.05] in comparison with the other groups. Moreover, in this group, necrosis of hepatocytes, cytoplasmic vacuolations, and lymphocytic inflammation were observed. Diabetic rats treated by root extract of P.f compared with diabetic group showed a significant decrease in these enzymes. In addition, in this group all of previous signs were improved. Root hydroalcoholic extract of P.f found to influence changes of aminotransferases and prevent the histopathological changes of liver associated with alloxan diabetes in rats