ABSTRACT
Human T-cell Lymphotrophic virus type 1 [HTLV-1] has infected more than 20 million people worldwide. Northeast of Iran, Mashhad, the capital of Razavi Khorasan Province, is endemic for HTLV-1 with a prevalence of 3% among general population. We evaluated the ICSI outcome in our program for [HTLV-1] serodiscordant couples [SDCs] with the female infected in comparison with control group. This study was performed between 2007 and 2011 in Novin Infertility Treatment Center [Mashhad, Iran]. We examined 32 ICSI cycles of HTLV-1 infected women in comparison with an age matched control group [n=62]. ICSI outcome was compared regarding fertilization rate [FR], embryo quality parameters, implantation rate [IR], clinical pregnancy rate [PR], and abortion rate [AR]. Fertilization [p=0.15], implantation [p=0.33], and pregnancy rate [p=0.12] were similar between the groups. No difference was found regarding the number of transferred embryos [on day 2 or 3] and cryopreserved embryos, multiple pregnancies, or abortion rates between the groups. Our results suggest that the embryo quality and ICSI outcome are not affected by HTLV-1 infection in serodiscordant couples. The major finding of this study is that the outcome of ICSI in HIV-I-infected patients and seronegative controls is similar.
ABSTRACT
Acinetobacter spp. emerged as an opportunistic pathogen for hospital-acquired infections. Recently, increasing antibiotic resistance among Acinetobacter spp. has worsened the problem. The aim of this study was to investigate the emerging trend of infection due to Acinetobacter in Ghaem University Hospital, Mashhad during 2006-2012. The demographic data and information about redisposing factors was collected. Appropriate bacteriological samples were collected and Acinetobacter spp. was isolated. Antibiotics susceptibility pattern of these isolates against different antimicrobials agents was determined. Results confirmed that Acinetobacter spp. cause 20.9% of nosocomial infection during this period. The trend of Acinetobacter nosocomial infection was increasing and patients with risk factors such as COPD, bronchectasia, diabetes mellitus were more prone to infection. There was significant association between these infections and invasive procedures such as catheterization, mechanical ventilation and broad-spectrum antibiotics usage. Conclusion: Understanding trends in causative organisms of nosocomial infection can help us to better define our infection control policy