ABSTRACT
Mirazid is a trade name of the purified oleo-gum resin extract from myrrh of commiphora molmol tree. It is used for treatment of schistosomniasis either haematobium or mansoni. This experimental model was done to demonstrate the histological, histochemical and ultrastructural changes of mirazid on the kidney of both adult golden hamsters and those infested with schistosoma haematobium. Forty two groups. adult male golden hamsters were used in this study. Half of them were divided into The control animals were given normal saline and the, treated animals were given mirazid. The rest of animals were infested with schistosoma haematobium parenterally.Eight weeks post infestation they were divided into two equals groups, the infested non-treated animals were given normal saline and the fourth group infested treated animals were treated with mirazid. All animals were given the treatment by intraperitoneal injection once daily for 3 days. After 24 hours from the last dose, kidney specimens were prepared to demonstrate the histological, histochemical and ultrastructural changes. Light microscopic examination of kidney slices of the infested non treated animals showed variable degrees of glomerular degeneration. There was hyaline material deposition in renal tubules. There was an increase in collagenous fibers depsition in the glomerular capillary tufts and in Bowmanis capsule. PAS reaction was decreased in the basement membranes of renal tubules and in brush borders of proximal convoluted tubules. The infested treated animals showed an obvious improvement in the glomeruli with marked reduction in hyaline immaterial deposition. There was a decrease in collagenous fibers deposition and PAS reaction in the renal glomeruli and tubules. Electron microscopic examination of the infested non treated kidney showed enlarged and, broad podocytes around a thick basement membrane of the capillary endothelium. The filteration slits were markedly decreased in number or completely disappeared. After treatment, the majority of podocytes regained their numerous minor processes and filteration slits inbetween. In conclusion, mirazid could be considered a safe and effective schistosomicidal drug