ABSTRACT
Statement of the Problem: Various researchers have suggested the use of beta 2-adrenergic receptor antagonists in prevention or treatment of bone resorption
Purpose: This study aimed to evaluate the effect of beta 2-adrenergic receptor antagonists on number of osteoclasts and osteoblasts involved in the healing of extraction socket of maxillary first molar in rats
Materials and Method: Maxillary first molars of 40 rats were extracted and divided into two groups. The test group received 0.1 mg/kg propranolol intraperitoneally daily. The controls received normal saline. At days 7, 14, 21 and 28 post-extraction, 5 rats were euthanized from each group. Maxillary bone was resected and the mean number of osteoblasts and osteoclasts in tooth socket was measured
Results: After 1 week, the number of osteoclasts in the controls was significantly higher than the test group. A significant increase in the number of osteoclasts in both groups at week 1 was observed compared to the following weeks [p< 0.05]. The number of osteoblasts in the controls at second week reached its maximum rate but stayed constant in the 3[rd] and 4[th] weeks. Osteoblasts in the test group increased similar to the controls but reached its maximum at 3[rd] week and showed a significant increase compared to the controls [p< 0.05]
Conclusion: Beta 2 adrenergic receptor antagonists decrease the number of osteoclasts and increase the number of osteoblasts during extraction socket healing
ABSTRACT
Giant cell fibroma of the tongue is a rare benign fibrous tumor of connective tissues in the oral cavity, very few of which have been reported. This benign neoplasm has a predilection for the gingiva and usually occurs in women under 30. Since this tumor is clinically, and especially histopathologically, placed in the differential diagnosis list of benign and malignant mesenchymal tumors, its proper diagnosis is of great significance because widespread and unnecessary surgeries are avoided as a result. The aim of the present report is to present a case of the tumor in the tongue of a 65-year-old man. The fibroma is a benign fibrous tumor of connective tissues which is microscopically classified in differential diagnosis with other soft tissue tumors since its proper diagnosis prevents from extensive and unnecessary surgeries on the patient
ABSTRACT
A 28-year old patient was referred for endodontic treatment of his left mandibular second molar. The patient had no history of systemic diseases and his chief complaint was spontaneous pain in left posterior region of mandible. Clinically, there was a deep caries in the left mandibular second molar. Radiographic examination of this tooth revealed a long crown containing large pulp chamber and two short roots with a apically located furcation, indicating hypertaurodontism. After coronal access preparation, five orifices were found including mesiolingual, mesiobuccal, distobuccal, mid-distal and distolingual. Subsequent to root canal preparation, a modified filling technique was used for canal obturation. After one year the treated tooth was symptom free