ABSTRACT
Cardiovascular drug interaction is the alarming and becoming leading cause of death in the society of Karachi Pakistan where the prevalence rate of CVS diseases in urban areas is very high. The aim was to evaluate the cardiovascular interactions in poly prescription in the city of Karachi, Pakistan. The methodology adopted forthis study is cross sectional study. In which verbally and signed informed consent prepare which help to limitize the biasness. In this study the determination of the percentage of interactions is about 30%.The gender which is most susceptible for interaction is females. The Significance or consequences of interaction would measured by minor, moderate and major level. In our study minor is about 28, moderate is about"! 9 while Major is about 9.The most untoward effects which was seen was bradycardia and the class of drug which lead for interaction is Beat and ACE blockers in the prescribing practice and some severe interaction lead to life threatening. The main result which is concluding forthis study is the huge number of interaction which is found in the prescription creates life threatening circumstances. With the proper consultation and time we can minimize the interaction as well as the health scenario can be improved and the quality of life can be improved