Adipose Tissue and Bone Marrow-Derived Mesenchymal Stem Cells Role in Regeneration of Cleft Alveolus in Dogs

Aim: This study was designed to evaluate the therapeutic potential of adipose tissue-derived mesenchymal stem cells (ATMSCs) compared to bone marrow-derived mesenchymal stem cells (BM-MSCs) on the regeneration of surgically createdcleft alveolus in dogs. Methods: Split mouth experimental study was performed on twelve healthy mongrel dogs. The dogswere divided into two groups (A and B): Ingroup A, the surgically created alveolus was transplanted with AT-MSCs,scaffold and growth factors at the experimental side (right side of the maxilla). Ingroup B, the surgically created alveoluswas transplanted with BM-MSCs, scaffold and growth factors at the experimental side (right side of the maxilla). In thecontrol side (left side of the maxilla), the surgically created alveolus was transplanted with scaffold and growth factors only.The flaps were replaced and sutured with resorbable sutures. Bone regeneration was evaluated clinically andradiographically after 1.5 and 3 months following dogs’ scarification. The data were evaluated with descriptive and t-testmethods (p=0.05). Results: Stem cells whether AT-MSCs or BM-MSCs accelerate the healing and regeneration of thedefected area by increasing the bone width and surface area; providing the bone quantity and quality as early as 1.5 and 3months. Conclusions: AT-MSCs and BM-MSCs are attractive tools in bone regeneration. AT-MSCs in experimental studiesshowed that their effectiveness is comparable to BM-MSCs, in addition to its low cost, ease of harvesting and saferprocedure to obtain stem cells as well as less risk of infection.

Relocation of the mental nerve in fenestrated mucosal flap vestibuloplasty

Candidates for this study were four patients complaining of pain and numbness during eating. The pain is due to the instability of the lower denture and flat lower ridge. The numbness is due to the pressure performed from the base of the lower denture to the area of the mental nerve. All patients were subjected to fenestrated mucosal flap vestibuloplasty with relocation or transpositioning of the mental nerve to a lower position, so that, the pressure performed by the denture base will be away from the mental nerve. The procedure is performed under local anesthesia in the outpatient clinic

effect of actinomycin [D] on healing of extraction stocket, clinico-experimental study

Administration of actinomycin "D" one or two weeks before extraction leads to retardation of healing. In general, the retardation of healing is even tolerable if compared with cancer chemotherapy as life saving measure or even effective treatment for the patient. However, it was recommended that patients undergoing chemotherapy should be seen by the oral surgeon before starting chemotherapeutic treatment for dental services and if possible, it is advisable to postpond the chemotherapy for at least 7 to 10 days after the extraction to allow primary epithelialization of the wound