ABSTRACT
Thirty patients with muscle-invading or high risk T1 [G3, associated carcinoma in situ, multifocality, >5 cm] bladder cancer were subjected to a protocol of transurethral resection of the bladder tumor [TURB], followed by concurrent cisplatin [20 mg/m2/day, 20 minutes infusion] and 5-fluorouacil [5 FU] [600 mg/m2/day, continuous infusion] administered on days 1-5 and 29-33 of radiotherapy [total dose to the bladder 55-60 Gy]. The response was evaluated by restaging TURB six weeks later. In case of invasive residual or recurrent tumor, salvage cystectomy was recommended. Twenty-one patients had no detectable tumor at restaging TURB and 12 patients were continuously free from tumor in their bladders. A superficial relapse occurred in three patients and a muscle-invasive relapse in six patients. The overall survival and survival with preserved bladder were 67% and 47%, respectively, at three years. The hematologic grade 3/4 toxicity occurred in 90% 13% and grade 3 diarrhea occurred in 7%