ABSTRACT
Objective To investigate the effect and safety of flurbiprofen axetil preemptive analgesia for patients undergoing laparoscopic cholecystotomy. Methods Sixty patients of ASA I- II undergoing selective laparoscopic cholecystotomy were randomly assigned to two groups: either to receive flurbiprofen axetil100 mg (flurbiprofen axetil group, n=30)or normal saline 10 mL (control group, n=30) before operation. Postoperative pain was treated by patient-controlled intravenous fentanyl analgesia. The extubation time, recovery time, and sedation-agitation scale (SAS) scores were estimated immediately after anesthesia. Postoperative fentanyl doses, side effects and the visual analgesia scale scores were recorded at 0, 2, 4, 6, 12, and 24 h after operation. Results The SAS score, VAS scores immediately after extubation and at different time points after operation in flurbiprofen axetil group were significantly lower than those in control group CP<0. 05). The flurbiprofen axetil group had significantly lower total dose of fentanyl (0-24 h after surgery) and significantly less nausea and vomiting than the control group CP< 0. 05). There were no significant differences in the extubation time and recovery time between the two groups. Conclusion Flurbiprofen axetil preemptive analgesia can alleviate acute postoperative pain of laparoscopic cholecystotomy, with no obvious adverse effect and without increasing the recovery time, making it worth popularizing in clinical practice.
ABSTRACT
Objective To evaluate the effect of intravenous dexamethasone on postoperative pain of microvascular decompression. Methods Totally 80 patients receiving elective microvascular decompression were randomized into two groups, with placebo or dexamethasone (10 mg, iv) given before the induction of anesthesia. The patients were generally anesthetized and the postoperative pain was managed with iv fentanyl using patient-controlled analgesia. The visual analog scale scores were recorded for pain at 2, 4, 6, 12 and 24 h after surgery and the side effects were also observed. Results The visual analog scale scores in the dexamethasone group were significantly lower than those in the placebo group at all time points(P<0. 05). The total dose of fentanyl (0-24 h after surgery) and the frequency of analgesic use in the dexamethasone group were significantly lower than those in the placebo group(P<0. 05). The incidence of nausea and vomiting in the dexamethasone group was lower than that in the placebo group(P<0. 05). Conclusion Dexamethasone (iv) before anesthesia induction can intensify the analgesic effect of fentanyl, with less side effects.