ABSTRACT
Introduction: Vaccination in adult life is important not only to prevent deaths but also to improve survival and reduce complications and severity of certain communicable diseases. It is a bitter fact that adult immunization coverage is below even 2 % in most of the countries. Knowledge and attitudes related to adult vaccination among medical professionals should also be emphasized as a starting point. Objectives: to assess knowledge, attitude and practice of adult immunization among resident doctors and to estimate adult immunization status among the respondents. Materials & Methods : A cross sectional study was carried out in resident doctors (junior residents and 1st year residents) of tertiary care medical institutes of Ahmedabad city, Gujarat. On the basis of the eligibility criteria (those who gave consent) 244 participants were finally got enrolled for the present study. Pre-tested questionnaire was use for data collection. Results: Mean age of study participant was 26.43 years and mean experience was 1.95 years. Among all adult vaccination status, Hepatitis B vaccination coverage was the highest (75%) followed by Human Papilloma Virus vaccination coverage which was 24.5% (25 out of 102 female). Most of the participant had correct and complete knowledge of vaccines named hepatitis B (82.4%), Rabies 187 (76.6%), Hepatitis A (70.9%), dPT/dT(69.7%) and Pneumococcal (66.4%). Conclusion: Hepatitis B was found to be the “best known, best practiced” adult vaccine thus far. There were wide variations with regards to attitude and practices of different adult vaccines among the respondents.
ABSTRACT
Background & Objectives: Acute Lymphoblastic Leukemia (ALL) is the most common childhood malignancy, with an annual rate of 3 to 4 cases per 1,00,000 children. ALL patients are treated with chemotherapeutic agents and cranial irradiation. Long-term sequelae of treatment are impaired intellectual and psychomotor functioning, neuroendocrine abnormalitites, impaired reproductive capacity, cardiotoxicity and second malignant neoplasms are being reported with increased frequency in the survivors. Among second neoplasms observed after treatment of ALL, central nervous system (CNS) tumors in patients treated with cranial irradiation are the most common. Others are Lymphoma, Acute Myeloid Leukemia (AML) and Thyroid Cancer. Methodology & Results: We are reporting four cases ,who developed ALL at the age of 8,6,4 and 25 years respectively(among that case 1 & case 2 are siblings) and were treated with chemotherapy and cranial irradiation. They developed Astrocytoma Grade-4 , Alveolar Soft-Part Sarcoma(ASPS) , Anaplastic Large Cell Medulloblastoma & Ewing’s Sarcoma at, 12 , 15, 8, 12 & 26 years of age respectively. Conclusion: Oncologists should make sure about the radiation doses before starting treatment and they should keep CMMR-D as a possibility in pediatric patients with siblings having h/o malignancy.