Epigenetic research progress in colorectal cancer / 中南大学学报(医学版)

Colorectal cancer is one of the common malignant tumors, which seriously threatens human health. Its morbidity and mortality rank the third and the second among all malignant tumors. The progress of colorectal cancer is a complex process involving the accumulation of genetic and epigenetic changes. Epigenetic changes of colorectal cancer mainly include DNA methylation, histone modification, non-coding RNAs (such as microRNAs and lncRNAs), which are of great significance to early diagnosis and prognosis evaluation, and to chemosensitivity assessment for colorectal cancer, providing a new thought for the treatment of colorectal cancer.

Male breast cancer:a report of 17 cases / 中国普通外科杂志

Objective To explore the diagnosis,treatment and prognosis of male breast cancer.Methods The clinical data of 17 male patients with breast cancer were analyzed retrospectively.Results The average age of these 17 patients was 59.6 years.In these 17 male cases,the breast cancer in 3 cases was stageⅠ,in 5 cases stageⅡ,in 7 cases stage Ⅲ,and in 2 cases stage Ⅳ.The major pathological type was typical invasive ductal carcinoma.The breast cancer positive rates of estrogen receptor was 82.4 % and progestogen receptor(PR) was 72.5 %.All of these cases were treated by radical operation and postoperative adjuvant radiotherapy,endocrine therapy and(or) chemotherapy.One patient was lost to follow-up,2 died of non-tumor disease 8 months and 3 years after operation,respectively,and the other 14 have survived for 1-12 years after operation.Conclusions Male breast cancer is an uncommon disease,age of onset is more advanced,and the misdiagnostic rate is high.Tamoxifen is the first choice of hormone therapy.Many factors influence the prognosis of male breast cancer,the most important of which are the TNM stage of tumor,and condition of lymph node involvement.