ABSTRACT
El genero Helicobacter es un taxón que ha experimentado una notable expansión, tanto desde el punto de vista de las especies que lo componen hasta ahora (19), como de los animales reservorios donde han sido encontradas. Algunas de estas especies pueden colonizar la mucosa gástrica y otras la mucosa intestinal. Muchas de ellas han sido consideradas como agentes zoonóticos y es posible que, en el futuro, nuevas especies sean agregadas a este género y muchas de aquellas encontradas exclusivamente en animales pueden ser aisladas del hombre y de otros huéspedes
Subject(s)
Helicobacter/classification , Zoonoses/epidemiology , Disease Reservoirs , Helicobacter/isolation & purification , Helicobacter/pathogenicity , Intestinal Mucosa/microbiology , Gastric Mucosa/microbiology , Host-Parasite InteractionsABSTRACT
The participation of the flagella of a virulent strain (O52) of campylobacter jejuni subsp. jejuni in the adhesion to HEp-2 cells and their inhibition by means of homologous polyclonal antibodies, moniclonal antiflagella antibodies and colostral natural antibodies (IgA) was studied. An aflagellated strain (T1) was used as negative control. Adhesion was observed in higher rates with O52 strain (72 percent) than with T1 strain (27,5 percent). Polyclonal, monoclonal and colostral antibodies inhibited O52 strain adhesion in more than 70 percent (p<0,001). T1 strain adhesion was inhibited only by polyclonal and colostral natural antibodies. Our results suggest that the flagella of C. jejuni subsp. jejuni could participate effectively in the adhesion process. However, the inhibition of T1 strain by polyclonal and colostral antibodies suggest the existence of other kinds of adhesins in the bacterial surface