ABSTRACT
Cholelithiasis is a disease of extrahepatic biliary system, which constitute hepatic ducts, common hepatic duct, cystic duct, gallbladder and common bile duct. There is no definite etiopathogenesis of this disease. But it has an established relation with 5 F [fatty, fertile, flatulent, female of fifty]. This hypothesis is not proved scientifically. Present paper is an attempt to evaluate the hypothesis of this 5 F. For this purpose we conducted clinical study at out patient department of A.K. Tibbia College Hospital A.M.U., Aligarh. A total of 110 patients were registered and admitted in the in-door patient department. Clinical and socio-economic data were recorded. Out of 110, 101 patients were female, from different sections of the society. In the outcome of the study we found that there was no relation of the etiopathogenesis of cholelithiasis with 5 F. Only one F is found that majority of sufferers are female. We concluded that gall-stone is a disease of multifactorial etiopathogenesis. It is evident that trend is being changed, may be due to environmental effect