ABSTRACT
Background: \r\n', u'In the antituberculosis chemotherapy, shortening treatment course, and applying new high effective methods are top prioritized. Of which,the immunotherapy with M vaccea an environmental saprophyte, combined with the antituberculosis medicines all over the world has been applied since 1985, aimed to enhance the host immune responses.\r\n', u'Objectives:\r\n', u'To evaluate the results after 6 months of shortened course anittuberculosis chemotherapy by combining the immunotherapy withM vaccae.\r\n', u'Subjects and method: \r\n', u'233 newly diagnosed pulmonary tuberculosis patients with AFB smear (+) selected from Centers for Tuberculosis Control in some districts of Ha Tay and Ha Noi. They are 15 above, and not the pregnant, breastfeeding, diabetes, HIV infections, and hepatitis B (Unnecessary) \r\n', u'Dividing randomly into 2 groups, group A was in treatment of the standard 8 month chemotherapy regimen, and group B was treated in a shortned 6 month chemotherapy regimen in combination with immunotherapy by using M. vaccae vaccine. \r\n', u'Results:\r\n', u'The rates of AFB (-) sputum of group B were 98,2% and 100% respectively, the rates of the group A were 97,4% and 99% respectively after 2 and 6 months of treatment. There are 88.5% and 100% for group B, 85.6% and 98.8% for group A at the same time to achieve a negative sputum culture for M. tuberculosis. IgM responses against M. tuberculosis sonicated antigen before and after the follow-up time in Group A are not changed, whereas this level of the immunotherapy group had reduced significantly at the 6th moth (P<0.05). There is no responses in IgC to M. tuberculosis of both groups during the same follow-up period. The mean weight of patients in group B was higher than that of group A after 2 and 6 months of treatment.\r\n', u'Conclusion:\r\n', u'M. vaccae vaccine brings good benefits when be combined with the chemo-immunotherapy for newly diagnosed pulmonary tuberculosis patients with AFB smear (+). The negative sputum indicators and clinic improvements in the chemo- immunotherapy group of treatment are better than that of chemotherapy only. This study created more effective method for treating tuberculosis infection.\r\n', u'
Subject(s)
Tuberculosis , Tuberculosis , Mycobacterium tuberculosisABSTRACT
Background: Soc Son is mountainous, poorest district of Ha Noi, the rate of malnourished children was highest level (28,2% in 2003). Objectives: Description and assessment on the effectiveness of microcredit program for developing household economy and the impact of microcredit program on care for pregnant women, children and nutrition situation for children in 7 communes of Soc Son district in 3 years (2003-2006). Subjects and method: 167 poor households with malnourished child/children or pregnant women with low weight gain which were provided loans in 7 communes of Soc Son district; 169 children were born after 1/6/2001 and their mother in 167 households above. Method: cross-sectional descriptive method combine comparative analysis, using interview ballot, growth chart of National Institute of nutrition. Data processing by software EPI 6.0 and SPSS/PC 12.0. Results: The microcredit program had helped 95,0% households improve their economy remarkably, 54,5% of the households had improved income and food security. These improvements had influenced positively on practice of maternal and child care and malnutrition situation among children under 5 years old. The rate of pregnant women taking sufficient rest before birth delivery and having appropriate workload during pregnancy increased by 29,7%. Low-birth-weight newborns (<2,500 gram) had decreased by 11,5%. The rate of children with more than 3 complementary meals had increased by 8,5%. Malnutrition prevalence of children under 5 years old in 7 communes had decreased by 6,9%. Conclusion: The program has contributed to lower malnutrition prevalence of children under 5 years old in Soc Son district by 6,6%.