ABSTRACT
Gonadotropin-Releasing Hormone agonists [GnRHa] are used to improve the final adult height in short stature children. There are limited studies which address the potential side effect of these agents: excessive weight gain. We have followed girls with rapidly progressive puberty receiving GnRHa and results were focused on the effect of treatment on final height, weight and body mass index. Thirty girls between 8.5 and 12 years with short stature and predicted adult height of less than 155 cm were enrolled in the study. All had rapidly progressive puberty. Weight and height measurements were done at the beginning of treatment, 6 and 12 months after starting and 6 and 12 months after the cessation of treatment Bone age and stages of puberty were estimated at the beginning of treatment, after 12 months of starting and 12 months after the treatment was stopped. Predicted adult height [PAH] changes during treatment were not significant There was no significant difference between final height and weight according to the body mass index [BMI], PAH or bone age. We conclude that girls with genetic short stature and rapidly progressive puberty will not benefit receiving a one-year course of GnRHa and there is no significant difference between the final height and final weigh among children according to BMI
ABSTRACT
This study was aimed to evaluate the situation of congenital hypothyroidism [CH] in Guilan using the screening program and determine the correlation of CH with birth weight, gestational age and seasonality. During 2006 to 2010, in Guilan province, neonatal screening for CH by measurement of serum TSH level was performed in 3-5 days after birth. All neonates with TSH level >/= 5mu/l were referred to endocrinologists and serum TSH, T3 and T4 were measured. Based on public health data and profiles, total number of newborns, gestational age, route of delivery, birth season and birth weight in all screened neonates was reviewed and for ones with CH, their TSH measurements was also recorded. During 5 years, 119701 neonates were screened and CH was confirmed in 10.8% [221] of the referral cases [prevalence=1:542]. No significant statistical difference was seen between gender and birth season among patients with CH and the rest of the population. Interestingly, low birth weight [LBW] [31% vs. 4.9%, P<0.01], postdate delivery [1.4% vs. 0.2%, P<0.01] and macrosomia were more prevalent in CH versus normal population [Odds ratio for post-date delivery was 6.9 and for LBW was 3.2]. Rate of normal vaginal delivery [NVD] was significantly higher in neonates with CH compared to normal population [39.2% vs. 29.2%, P=0.01]. LBW, postdate delivery and macrosomia are risk factors for CH. No association between sex, birth season or caesarian section delivery was seen