ABSTRACT
To study a serie of superficial tumors of the bladder and to assess the prognostic significance of p53, Ki67, PCNA and bc!2 in these tumors. We studied 59 bladder tumors: 43 pTa and 16 pTl. All Patients had cystoscopy 3 months after the resection and tumors that did not recur had a minimum follow up of 5 years. Age more than 65 years [p = 0,001], multifocality [p=0,022] and tumoral size > 3 cm [p = 0,022] were correlated with the recurrence. The expression of p53 was correlated with the recurrence in the year following the tumoral resection [p = 0,035]. That of of Ki67 was correlated with the histological grade [p = 0,03] and stage [p=0,002]. Our results suggest to practise regular endoscopic controls during the first year following the resection of the primitive tumor if it expresses p53. The immunohistochemical expression of Ki67 being correlated with the grade, this marker could help to better classify the tumors of intermediate grade
ABSTRACT
To study, through a series of superficial bladder tumors, the prognostic factors of recurrence and tumoral progression. this is a retrospective study of a series of 59 urothelial tumors of the bladder at stage pTa or pTl. The following parameters were considered: age, sex, treatment, stage and grade. The chi square test was used in search of a correlation between the different parameters and the course [recurrence and progress] of the disease. A multivariate analysis was undertaken by integrating factors correlated with the course. Thirty two tumors [54%] had recurred versus 27 [46%] without recurrence. Light tumors [25%] progressed in grade and 4 [12,5%] had become infiltrative. Age beyond 65 years. tumoral size > 3 cm and rnultifocality were predictive factors of recurrence with a relative risks of 2.36, 3,28 and 3,88 respectively. In a multivariate analysis, these factors remained significant with adjusted relative risks respectively of 1,36, 1,6 and 1,7