ABSTRACT
Background: In the present study we are going to evaluate lipid profile and Electrolytes levels (Sodium, Potassium in Serum & Urine) in Essential Hypertensive and in healthy controls in North Indian Population. Methods: A total of 210 age and sex matched E. hypertensive & healthy controls were included in our study from outpatient department (OPD) of Medicine in King George Medical University, Lucknow, India. First group consist of 110 subjects were known E. hypertensive patients (B.P ≤ 139/89mm of Hg). Another group is control group consist of 100 subjects who were healthy controls (B.P ≤ 120/80mm of Hg) with no history of hypertension. Fasting venous blood sample was collected from all the subjects in plane vacationer and the sample was centrifuged for the estimation of lipid profile & electrolyte i.e. Sodium (N+) & Potassium (K+). Lipid profile was measured with an automated analyzer (Biochem) & Electrolytes was measured using ion-selective electrolyte auto-analyzer in the Clinical lab of biochemistry in KGMU. Results: After analyzing results almost control subjects had normal lipid profile level. In patients of E. hypertension there was a highly significant increase in serum Total Cholesterol (p˂0.0001), LDL-Cholesterol (p˂0.0001) & Triglycerides (p˂0.001). HDL-Cholesterol (p˂0.03) is also significant as compare to controls. Not significant difference was found in serum sodium & potassium level. The Urinary Na+ levels were significantly lower in E. hypertensive patients when compared to controls while Urinary K+ levels were not significant. Conclusion: So we conclude that dyslipidemia is associated with essential hypertension this may due to the genetic predisposition, secondary lifestyles, fatty food consumption, saturated fat, cholesterol in the food increase the blood cholesterol and saturated fat is the main culprit. Essential hypertensive is linked with increased Na+, K+ - ATPase activity and increased renal tubular sodium reabsorption.
ABSTRACT
Background: Type 2 diabetes has become a global epidemic. Tinospora cordifolia is being used in the treatment of type 2 diabetes since ancient times. It is a common misconception that Ayurvedic medicines are always safe. In fact, they also pose serious health risks either in the form of adverse reactions or in the form of drug interactions. Hence this study was undertaken to study the efficacy and safety of Tc on human subjects. Methods: We recruited 40 type 2 diabetic patients who were on oral hypoglycaemic agents. These patients were then randomly divided into two groups, A and B. Patients in group A continued with their anti-diabetic medications while in group B Tc was given at a dose of 500 mg three times daily along with their conventional medications. The fasting and post prandial blood glucose levels, renal function tests and liver function tests were recorded at baseline, 3 months and 6 months. Results: During the course of study we observed a decrease in the fasting and post prandial blood glucose levels of the patients. No significant change was observed in the renal function tests and liver function tests and no other event of any adverse drug reactions were recorded. Conclusion: Tinospora cordifolia (Tc) is effective as an add-on therapy in patients with type-2 diabetes. There is no negative impact of Tc on the renal as well as liver function tests.