Aluminum cation feed toxicity to male mice

Alumnum phosphide is used in fumigation, where phosphin is liberated and AL [OH][3] is formed as a secondary residue which may contaminate wheat or flour. The toxic effect of Al residue of 0.2 gm/kg/b.wt. in administered wheat [173-183 gm/mice] was investigated. Acetyl cholinesterase [AChE] wa not significantly affected. Both acid and alkaline phosphatases [APas and AlPase] were slightly stimulated. On the other hand, adenosine triphosphatae [ATPase] activity and levels of the Neurotransmitters amino acids gamma-amino butric acid [GABA] and glutamic acid were significantly inibited suggesting that these biochemical targets may be the main site of action of Al toxicity