ABSTRACT
Background:Non-high density lipoprotein cholesterol has been shown to be a predictor of initial coronary heart disease events and arthrogenic. Women from Madurai have been shown to develop dyslipedemias from an early agerequiring surgical intervention when compared to women from other regions of India. This observational study was undertaken to find if the women had a higher risk for CHD when compared to men from the same region. Methods: 50 subjects (n=50) were inducted into this study with 26 (52%) of them were males and 24 (48%) of them were females.Patients with significant past history of major illness were excluded, including dyslipidemias, Diabetes mellitus, hypertension, myeloproliferative disorders, cardiac diseases and alcohol addiction. Blood lipid profile, Pulsed Doppler profile of right brachial artery blood flow velocities, Brachial arterial wall thickness, Blood pressure were measured.Results: In males there was significant correlation between Non HDL–C peak Systolic velocity (PSV), wall thickness (WT) and systolic Blood pressure (SBP) (P< 0.01) and End diastolic velocity (EDV) (p<0.05). Females in addition correlated significantly with diastolic blood pressure (DBP) (p<0.05) and without correlation with EDV. Total cholesterol (TC) in males were significantly correlated to PSV, EDV, WT and SBP (p<0.01). In females TC was significantly correlated to PSV, WT and SBP (P<0.01) and with DBP and Age (P<0.05). Conclusion: Our results show that females in Madurai develop higher risk for CHD from an early age than men because, Non-HDL-C was correlated significantly with SBP and DBP, SPV and WT, where as in men there was no correlation with DBP, and TC was additionally correlated significantly with DBP and Age in females and not in males. Early intervention with life style changes, Dietary modifications and exercise program may mitigate these risk factors for CHD.