ABSTRACT
Sulfonamides were developed by the simple reaction of amino acid with p-toluenesulfonyl chloride and structures of the new products [2a, 2b and 2c] were confirmed by elemental and spectral analysis [FT-IR, [1]HNMR and[13]CNMR]. In vitro, developed compounds were screened for their antibacterial and antifungal activities against two sensitive bacteria belonging to both gram positive and gram-negative types and two fungi. The synthesized sulfonamides [2a, 2b, 2c] exhibited excellent antifungal activities against the tested fungi. Among the tested compounds 2a and 2b have marked activity against E. coli with zone of inhibition [mm] 22.3+/-0.11and 20.2+/-0.26 [MIC: 12.5[micro]g/mL, 12.5[micro]g/mL] and S. aureus with zone of inhibition [mm] 20.2+/-0.26 and 23.2+/-0.55 [MIC: 12.5[micro]g/mL, 6.25[micro]g/mL]. Compound 2c is moderately efficient towards E. coli [zone of inhibition [mm] 14.2+/-0.64, MIC: 100[micro]g/mL] and no activity against S. aureus