ABSTRACT
The present study aimed to clarify the effect of aqueous extracts of five plants [Nigella sativa, Aloe vera, Ferula assafoetida, Boswellia carterii Birdw and Commiphora myrrha] and their mixture on liver and kidney functions and protein profiles. Eighty adult male albino rats were divided into eight groups, the first served as control group, other groups were injected with alloxan [120mg/kg b.wt]. The second group served as diabetic rats, the third were treated with a mixture [0.1g/100g b.wt], the fourth was treated with Nigella sativa [0.1g/100g b.wt], the fifth was treated with Aloe vera [0.05 g/100g b.wt], the sixth was treated with Ferula assafoetida [0.1g/100g b.wt], the seventh was treated with Boswellia carterri Birdw [0.1g/100g b.wt] and the eighth group was treated with Commiphora myrrha [0.05 g/100g b.wt]. After thirty days of treatment half of each group was decapitated and the other one was left for 15 days without any additional treatment as recovery period to followup their hazards if present. The results revealed highly significant increase [p<0.01] in serum transaminases [aspartate [AST] and alanine [ALT]], alkaline phosphates [ALP], total bilirubin, urea and creatinine and recorded highly significant decrease [p<0.01] in serum total protein, albumin and globulin concentrations in the diabetic group when compared with normal rates. Otherwise, all plants extracts treated groups showed insignificant changes in the previous parameters when compared with control one. It seams, therefore that the water extracts of these plants and their mixture have protective effect against the side effects of alloxan on liver and kidney
ABSTRACT
In the current study, thirty male adult albino rats were used to investigate the effect of Boswellia Carterii Birdw [BCB] on carbohydrate metabolism in alloxan-induced diabetes. Rats were divided into three equal groups, control, diabetic non treated and diabetic BCB treated groups. After thirty days of treatment five rats of each group were sacrificed and the others were left without any additional treatment for another 15 days [recovery period] then were sacrificed. The body weight of each rat was determined at the beginning and the end of each period. Blood glucose, serum insulin and liver glycogen were determined for each rat at the end of each period. It was noticed that B.C.B treatment led to a significant improve in the decreased body weight, hyperglycemia, hypoinsulinemia, decreased liver glycogen caused by alloxan. And this improvement was also seen after the recovery period. B.C.B treatment led also to marked improvement in the histopathological degenerative changes in the beta cells of islets of Langerhans caused by alloxan after both the treated and recovery periods
ABSTRACT
The present study aimed to clarify the antidiabetic activity of Commiphora myrrha [CM] aqueous extract on thirty adult male albino rats, which were divided into two groups; the first served as a control group, the second was injected with alloxan [120mg/Kg body weight] and divided into two subgroups the first served as diabetic group, the second treated with [CM] water extract [0.05mg/100 gm bwt]. After 30 days of the treatment half of each group was sacrificed and the other half was left for other 15 days without any additional treatment [recovery period]. Our results revealed highly significant decrease [p< 0.01] in blood glucose level and highly significant increase in body weight of the diabetic rats with different histological changes in cells of islets of Langerhans. These histological and physiological changes were ameliorated in rats treated with CM. Water extract of CM has a definite hypoglycemic, hyperinsulinimic effect, on the other hand, a significant increase in body weight, beta cell number and liver glycogen contents were achieved. The results of the present study clarify the role of CM as an active antidiabetic plant and suggest a relationship between drenching CM extract and insulin production. Other of investigations want be done to detect effects of different doses and time intervals of CM in diabetic animals
ABSTRACT
In the current study, thirty adult male albino rats were used to investigate the effect of Ferula assafoetida on carbohydrate metabolism in alloxan-induced diabetes. Rats were divided into three equal groups, control, diabetic non-treated and diabetic Ferula assafoetida treated groups. After thirty days of treatment five rats of each group were sacrificed and the others were left without any additional treatment for another 15 days [recovery period] then were sacrificed. Body weight, blood glucose, serum insulin and liver glycogen content levels were determined for each rat at the end of each period. It was noticed that Ferula assafoetida treatment led to a significant improve in hyperglycemia, hypoinsulinemia, decreased liver glycogen and increased percentage of body weight change caused by alloxan. And this improvement was also seen after the recovery period. Ferula assafoetida treatment led also to marked improvement in the histopathological degenerative changes in the beta cells of islets of Langerhans caused by alloxan after both the treated and recovery periods