In vivo radiosensitization of nitroimidazole derivative [KIN-804] compared with misonidazole [MISO]

The effects of a single dose of KIN-804 and MISO on liver and Ehrlich solid carcinoma [ESC] have been studied in Swiss albino mice. KIN-804 and MISO were administered at doses of 800 and 400 mg/Kg body weight, respectively. Liver glucose-6-phosphatase [G-6-pase], glutathione content and superoxide dismutase of ESC, were measured at different times from drug administration. [G-6-pase] was elevated significantly 24 hours after MISO only, while GSH and SOD showed nearly the same changes after MISO and KIN 804. Therefore, KIN-804 is a less toxic radiosensitizer and should be implicated in clinical trials

Enzymatic changes in the gingival tissues after radiotherapy

Twelve subjects with radiosensitive malignancies in the head and neck and 12 control normal patients with healthy gingival tissues are included in this study. A single specimen was taken from the gingiva of control patients, while 3 specimens where taken from the radiotherapy patients [before, after, and 6 months later radiotherapy]. Lypholisation of the tissues was done and Apizym kit was used. The results showed significant biochemical changes in the enzymatic activities of the gingival tissues after radiotherapy. A difference is quite apparent between control and radiotherapy group, for all enzymes except for estraselipase and B-galactosidase. These changes are expected to participate significantly in the histopathochemical and clinical changes in the role tissue after radiotherapy