New derivatives of furocoumarins as potential photochemotherapeutic agents

New derivatives of linear and angular furocoumarins were synthesised for obtaining useful photosensitizing agents for treatment of psoriasis. The new compounds, 8-benzoyl-5,-5'-dimethylpsoralen [7b], 5-methyl-4'-phenylangelicin [10b] and their isomeric derivative 4,7 -dimethyl-4'-phenylallopsoralen [10c] were prepared starting from the coumarinic nucleus and condensing on it the furan ring. The photosensitizing activity of the prepared furocoumarins was tested on Bacillus subtilis