Incidence, diagnosis and management of peptic ulcer disease in two years 1989-1990, El-Minia governorate

This work included 128 cases with peptic ulcer syndrome that were studied to identify the most common causes of dyspepsia. Chronic gastric and duodenal ulcers represent 58.6% of cases and 25% of cases were functional dyspepsia secondary nonulcer dyspepsia. Most of cases with peptic ulcer were of middle aged males [31-40 years]. The presenting symptoms in cases with nonulcer dyspepsia may stimulate peptic-ulcer syndrome; however, the periodicity of symptoms is characteristic for peptic ulcer. Gastric ulcer is a common association with heavy smoking. The best diagnostic procedure for those cases was the fiber-optic endoscopy, where 84.1% of cases with duodenal ulcer and all cases with gastric ulcer were positively diagnosed. Barium studies with findings suggestive of peptic ulceration was found in about 50% of the cases. Medical treatment was successful in about 50% of the cases and surgical treatment was done in cases with complications and those not responding to medical treatment for six months

Clinicopathological and ultrastructural studies of the liver in diabetic patients

Ten patients with adult onset diabetes mellitus, presented with hepatomegaly, were studied. Liver function tests showed mild disturbances in phosphatase levels. The main histopathological changes were fatty change, nuclear vacuolation, round cell infiltrate in the portal tract, fibrous bridging and piecemeal necrosis. The main ultrastructural changes were filled with osmiophilic granular material. The microvilli of the hepatocytes were blunted or even absent. Space of Disse was collapsed by the enlarged von kupffer cells and ballooning of hepatocytes. The existence of these light and electron microscopic changes suggested that patients with glucose intolerance may develop hepatitis. Follow up of these patients with liver biopsy to assess the progression of these changes was recommended

Cardiac performance in patients with acute viral hepatitis

Clinical, electrocardiographic and hemodynamic studies were made in 75 patients with acute hepatitis. Stroke volume, cardiac output, contractility index and other parameters were measured by impedance cardiography. Evidence of an abnormal electrocardiographic changes and moderate impairment of cardiac function strongly suggested myocarditis in acute viral hepatitis