Expressions of cyclinE,cdk2 and p27~(kip1) in invasive pituitary adenomas and the clinical significance / 重庆医科大学学报

Objective:To study the expressions of cyclinE,cdk2 and p27kip1 in invasive pituitary adenomas and their relation to clinical biological behaviors. Methods:Western blotting analysis was adopted to detect the expressions of cyclinE,cdk2 and p27kip1 in 37 cases of noninvasive pituitary adenomas and 21 cases of invasive pituitary adenomas. Results:The expressions of cyclinE and cdk2 in invasive pituitary adenomas were significantly higher than those in noninvasive pituitary adenomas(both P