ABSTRACT
ABSTRACT Purpose: To develop a rabbit experimental study to test the hypothesis that surgical repair of hypospadias with severe ventral curvatures might be completed in one stage, if a graft, such as buccal mucosa, could be placed over the tunica vaginalis flap used in corporoplasty for ventral lengthening, with the addition of an onlay preputial island flap to complete the urethroplasty. Materials and methods: The experimental procedure with rabbits included a tunica vaginalis flap for reconstruction of the corpora after corporotomy, simulating a ventral lengthening operation. A buccal mucosa graft was placed directly on top of the flap, and the urethroplasty was completed with an onlay preputial island flap. Eight rabbits were divided into 4 groups, sacrificed at 2, 4, 8 and 12 weeks postoperatively, and submitted to histological evaluation. Results: We observed a large number of complications, such as fistula (75%), urinary retention (50%) and stenosis (50%). There were two deaths related to the procedure. Histological evaluation demonstrated a severe and persistent inflammatory reaction. No viable tunica vaginalis or buccal mucosa was identified. Conclusions: In this animal model, the association of a buccal mucosa graft over the tunica vaginalis flap was not successful, and resulted in complete loss of both tissues.
Subject(s)
Animals , Male , Urologic Surgical Procedures, Male/methods , Surgical Flaps/surgery , Urethra/surgery , Hypospadias/surgery , Postoperative Complications , Rabbits , Fibrosis , Urinary Fistula/etiology , Urinary Fistula/pathology , Disease Models, Animal , Epithelium/pathology , Hypospadias/pathology , InflammationABSTRACT
Os autores apresentam o caso de um paciente acromegálico portador de cardiomiopatia. Os dados clínico-patológicos sugerem que esta teria sido causada pela endocrinopatia. É feita uma revisäo sobre o envolvimento do sistema cardiovascular na acromegalia, com enfoque nos mecanismos patogenéticos que contribuem para a cardiomiopatia, incluindo uma discussäo sobre o efeito miocardiopático do hormônio do crescimento