ABSTRACT
Se hace estudio ultraestructural del bacilo de Hansen a 20.000 x en pellet y en vacuola del nódulo hanseniano activo. Se observa su pared celular, membrana plasmática mesosoma y nucleoide. En su citoestructura no se diferencia de otras bacterias ya sean éstas Gram positivas o Gram negativas. Solo las diferencia su ácido resistencia la cual le da sus características tintoriales especiales
Subject(s)
Mycobacterium lepraemurium/ultrastructureABSTRACT
Conventional vaccination is oriented toward the prevention of disease in individuals capable of developing normal immune responses. A new model of vaccination employing two microorganisms has been described for the correction of variable degrees of antigen-specifit deficiency in the development of effective cell-mediated immunity in two diseases, leprosy and cutaneous leishmaniasis, both of which are characterized by a spectrum of clinical manifestations. A schematic representation of the immunologic defect in the severe and progressive forms of these diseases and a possible mechanism for its correction using this vaccine model are presented. Immunotherapeutic and immunoprophylactic applications of the model are described, with particular reference to recent experience in the immunotherapy of localized cutaneous leishmaniasis. The efficacy, virtual absence of secondary effects, ease of administration and low cost of this therapeutic modality indicate that it offers an important option or field use in endemic of leishmaniasis
Subject(s)
Humans , Immunotherapy , Leishmaniasis/immunology , Leprosy/immunologyABSTRACT
Son resumidos los aspectos clínicos, histopatológicos e inmunológicos, compartidos por la lepra y leishmaniasis cutánea americana